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Protein-coding gene in the species Homo sapiens
Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene .[ 5] [ 6]
Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline . Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors . PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM][ 7]
Mechanism of activation [ edit ] PLD2 is activated by substrate presentation .[ 8]
PLD2 has been shown to interact with:
N -(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1 , IC50 = 20 nM.[ 20]
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Slaaby R, Jensen T, Hansen HS, Frohman MA, Seedorf K (December 1998). "PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation" . The Journal of Biological Chemistry . 273 (50): 33722–7. doi :10.1074/jbc.273.50.33722 PMID 9837959 . Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, Liscovitch M (February 2000). "Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains" . FEBS Letters . 467 (2–3): 326–32. doi :10.1016/S0014-5793(00)01174-1 PMID 10675563 . S2CID 21891748 . Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG (June 2000). "Inhibition of phospholipase D by amphiphysins" . The Journal of Biological Chemistry . 275 (25): 18751–8. doi :10.1074/jbc.M001695200 PMID 10764771 . Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, Du G, et al. (July 2000). 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The Journal of Biological Chemistry . 276 (30): 28252–60. doi :10.1074/jbc.M008521200 PMID 11373276 . Sarkar S, Miwa N, Kominami H, Igarashi N, Hayashi S, Okada T, et al. (November 2001). "Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator" . The Biochemical Journal . 359 (Pt 3): 599–604. doi :10.1042/0264-6021:3590599 . PMC 1222181 PMID 11672434 . Denmat-Ouisse LA, Phebidias C, Honkavaara P, Robin P, Geny B, Min DS, et al. (December 2001). "Regulation of constitutive protein transit by phospholipase D in HT29-cl19A cells" . The Journal of Biological Chemistry . 276 (52): 48840–6. doi :10.1074/jbc.M104276200 PMID 11687572 . Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, et al. (February 2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction" . The Journal of Biological Chemistry . 277 (8): 6542–9. doi :10.1074/jbc.M108047200 PMID 11741937 . Han JM, Kim JH, Lee BD, Lee SD, Kim Y, Jung YW, et al. (March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells" . The Journal of Biological Chemistry . 277 (10): 8290–7. doi :10.1074/jbc.M108343200 PMID 11744693 .
Activity Regulation Classification Kinetics Types
