CLDN15

CLDN15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4P79
Identifiers
Aliases	CLDN15, claudin 15
External IDs	OMIM: 615778; MGI: 1913103; HomoloGene: 8646; GeneCards: CLDN15; OMA:CLDN15 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	101,238,820 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	137,004,712 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; mucosa of ileum; ; germinal epithelium; ; mucosa of transverse colon; ; granulocyte; ; parietal pleura; ; right lobe of liver; ; left uterine tube; ; spleen;
	Top expressed in
	duodenum; ; crypt of lieberkuhn of small intestine; ; intestinal villus; ; granulocyte; ; jejunum; ; Paneth cell; ; epithelium of small intestine; ; ileum; ; left colon; ; oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; identical protein binding;
Cellular component	integral component of membrane; cell junction; plasma membrane; lateral plasma membrane; membrane; bicellular tight junction;
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ion transport;
	Sources:Amigo / QuickGO
Orthologs
	24146
	60363
	ENSG00000106404
	ENSMUSG00000001739
	P56746
	Q9Z0S5
	NM_138429; NM_001185080; NM_014343
	NM_021719
	NP_001172009; NP_055158
	NP_068365
	Wikidata
View/Edit Human	View/Edit Mouse

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Claudin-15 is a protein that in humans is encoded by the CLDN15 gene.^[5] It belongs to the group of claudins. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Tight junction. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN10.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106404 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CLDN15 claudin 15".
^ Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards | CLD15 Protein | CLD15 Antibody". www.genecards.org. Retrieved 2017-04-14.

External links

Human CLDN15 genome location and CLDN15 gene details page in the UCSC Genome Browser.

Kniesel U, Wolburg H (2000). "Tight junctions of the blood–brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307. S2CID 12132159.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Yi X, Wang Y, Yu FS (2000). "Corneal epithelial tight junctions and their response to lipopolysaccharide challenge". Invest. Ophthalmol. Vis. Sci. 41 (13): 4093–100. PMID 11095601.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments". J. Am. Soc. Nephrol. 13 (4): 875–86. doi:10.1681/ASN.V134875. PMID 11912246.
Colegio OR, Van Itallie CM, McCrea HJ, et al. (2002). "Claudins create charge-selective channels in the paracellular pathway between epithelial cells" (PDF). Am. J. Physiol., Cell Physiol. 283 (1): C142–7. doi:10.1152/ajpcell.00038.2002. PMID 12055082. S2CID 9555118.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Van Itallie CM, Fanning AS, Anderson JM (2003). "Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins". Am. J. Physiol. Renal Physiol. 285 (6): F1078–84. doi:10.1152/ajprenal.00116.2003. PMID 13129853.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106404 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001739 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CLDN15 claudin 15".

[6] Database, GeneCards Human Gene. "CLDN15 Gene - GeneCards | CLD15 Protein | CLD15 Antibody". www.genecards.org. Retrieved 2017-04-14.

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References

External links

Further reading