CDH6

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CDH6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LND
Identifiers
Aliases	CDH6, CAD6, KCAD, cadherin 6
External IDs	OMIM: 603007; MGI: 107435; HomoloGene: 21027; GeneCards: CDH6; OMA:CDH6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5p13.3 Start 31,193,686 bp End 31,329,146 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 A1 Start 13,028,787 bp End 13,173,761 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell kidney tubule tibial arteries human kidney endothelial cell vena cava gallbladder sural nerve lateral nuclear group of thalamus metanephric glomerulus Top expressed in internal carotid artery external carotid artery hair follicle ascending aorta aortic valve Rostral migratory stream renal corpuscle efferent ductule ciliary body iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding cytoskeletal protein binding protein homodimerization activity cadherin binding Cellular component integral component of membrane plasma membrane membrane cell surface catenin complex Biological process Notch signaling pathway cell adhesion adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules cell-cell junction assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion mediated by cadherin cell-cell adhesion cell morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1004 12563 Ensembl ENSG00000113361 ENSMUSG00000039385 UniProt P55285 P97326 RefSeq (mRNA) NM_004932 NM_001362435 NM_007666 RefSeq (protein) NP_004923 NP_001349364 NP_031692 Location (UCSC) Chr 5: 31.19 – 31.33 Mb Chr 15: 13.03 – 13.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

Further reading

• MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation". Am. J. Reprod. Immunol. 39 (2): 96–107. doi:10.1111/j.1600-0897.1998.tb00341.x. PMID 9506208. S2CID 23871813.
• Suzuki S, Sano K, Tanihara H (1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul. 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658.
• Paul R, Ewing CM, Robinson JC, et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma". Cancer Res. 57 (13): 2741–8. PMID 9205085.
• Getsios S, Chen GT, Stephenson MD, et al. (1998). "Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium". Dev. Dyn. 211 (3): 238–47. doi:10.1002/(SICI)1097-0177(199803)211:3<238::AID-AJA5>3.0.CO;2-I. PMID 9520111.
• Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics. 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235.
• Shimoyama Y, Takeda H, Yoshihara S, et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin". J. Biol. Chem. 274 (17): 11987–94. doi:10.1074/jbc.274.17.11987. PMID 10207020.
• Shimoyama Y, Tsujimoto G, Kitajima M, Natori M (2001). "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins". Biochem. J. 349 (Pt 1): 159–67. doi:10.1042/0264-6021:3490159. PMC 1221133. PMID 10861224.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• CDH6 human gene location in the UCSC Genome Browser.
• CDH6 human gene details in the UCSC Genome Browser.