PIGK

PIGK
Identifiers
Aliases	PIGK, GPI8, phosphatidylinositol glycan anchor biosynthesis class K, NEDHCAS
External IDs	OMIM: 605087; MGI: 1913863; HomoloGene: 4002; GeneCards: PIGK; OMA:PIGK - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	77,219,430 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	152,980,408 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Achilles tendon; ; stromal cell of endometrium; ; islet of Langerhans; ; retinal pigment epithelium; ; right coronary artery; ; right ventricle; ; kidney tubule; ; glomerulus; ; popliteal artery;
	Top expressed in
	spermatocyte; ; spermatid; ; cingulate gyrus; ; Ileal epithelium; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; plantaris muscle; ; supraoptic nucleus; ; calvaria; ; decidua;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GPI-anchor transamidase activity; peptidase activity; cysteine-type peptidase activity; GPI anchor binding; protein binding; hydrolase activity; protein disulfide isomerase activity;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; endoplasmic reticulum membrane; membrane; GPI-anchor transamidase complex; endoplasmic reticulum;
Biological process	GPI anchor biosynthetic process; attachment of GPI anchor to protein; protein localization to cell surface; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10026
	329777
	ENSG00000142892
	ENSMUSG00000039047
	Q92643
	Q9CXY9
	NM_005482
	NM_025662; NM_178016
	NP_005473
	NP_079938; NP_821135
	Wikidata
View/Edit Human	View/Edit Mouse

GPI-anchor transamidase is an enzyme that in humans is encoded by the PIGK gene.^[5]^[6]

Template:PBB Summary

Interactions

PIGK has been shown to interact with PIGT^[7] and GPAA1.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039047 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yu J, Nagarajan S, Knez JJ, Udenfriend S, Chen R, Medof ME (December 1997). "The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase". Proc Natl Acad Sci U S A. 94 (23): 12580–5. Bibcode:1997PNAS...9412580Y. doi:10.1073/pnas.94.23.12580. PMC 25045. PMID 9356492.
^ "Entrez Gene: PIGK phosphatidylinositol glycan anchor biosynthesis, class K".
^ Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (April 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16). United States: 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Ohishi, K; Inoue N; Maeda Y; Takeda J; Riezman H; Kinoshita T (May 2000). "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins". Mol. Biol. Cell. 11 (5). UNITED STATES: 1523–33. doi:10.1091/mbc.11.5.1523. ISSN 1059-1524. PMC 14864. PMID 10793132. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34). United States: 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

External links

PIGK human gene location in the UCSC Genome Browser.
PIGK human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039047 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9356492-5] Yu J, Nagarajan S, Knez JJ, Udenfriend S, Chen R, Medof ME (December 1997). "The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase". Proc Natl Acad Sci U S A. 94 (23): 12580–5. Bibcode:1997PNAS...9412580Y. doi:10.1073/pnas.94.23.12580. PMC 25045. PMID 9356492.

[entrez-6] "Entrez Gene: PIGK phosphatidylinositol glycan anchor biosynthesis, class K".

[pmid12582175-7] Ohishi, Kazuhito; Nagamune Kisaburo; Maeda Yusuke; Kinoshita Taroh (April 2003). "Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge". J. Biol. Chem. 278 (16). United States: 13959–67. doi:10.1074/jbc.M300586200. ISSN 0021-9258. PMID 12582175. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid10793132-8] Ohishi, K; Inoue N; Maeda Y; Takeda J; Riezman H; Kinoshita T (May 2000). "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins". Mol. Biol. Cell. 11 (5). UNITED STATES: 1523–33. doi:10.1091/mbc.11.5.1523. ISSN 1059-1524. PMC 14864. PMID 10793132. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid12052837-9] Vainauskas, Saulius; Maeda Yusuke; Kurniawan Henry; Kinoshita Taroh; Menon Anant K (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". J. Biol. Chem. 277 (34). United States: 30535–42. doi:10.1074/jbc.M205402200. ISSN 0021-9258. PMID 12052837. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

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Interactions

References

Further reading

External links