= Haplogroup L2a's Inclusion Of Medical Data, Dubious Conclusions

" In patients who are given the drug stavudine to treat HIV, Haplogroup L2a is associated with a lower likelihood of peripheral neuropathy as a side effect.[15]" It is highly dubious to link the development of peripheral neuropathy resulting from an ART drug, to haplogroups. In fact it's absurd if you think about it. A female haplogroup is just a random piece of dna on the mitochondrial dna. Any correlation with the effect of a drug almost has to be coincidental.

Definition of mtDNA haplogroups

What is the definition of each of the mtDNA haplogroups? I.e. by which mutation it characterized? --Maruvkay

See http://www.phylotree.org/ --192.172.8.13 (talk) 17:01, 4 September 2009 (UTC)[reply]

Dividing

I think that it is recommended separating this article in two: L2 and L2a1. --Maulucioni (talk) 13:23, 17 June 2011 (UTC)[reply]

Why L2a1? The L2 article needs extenstive work first. After it is complete, then we should turn to other subclades like L2a or L2b. L2a1 is very deep. --Brout8 (talk) 19:23, 17 June 2011 (UTC)[reply]

The development of L2a1 is too unequal compared to the other clades. I still do think that they should be separated. In the other hand, I see you have added information on L2e, but I haven't found anything in Kivisild 2004, only from 2008 sources. --Maulucioni (talk) 20:21, 17 June 2011 (UTC)[reply]

Don't get caught up in the names. You have to look at the sequences. Kivisild mislabeled what is now know as L2e using only HVS-I. It is properly named L2e now. L2a1 might be the better studied sublade, but this doesn't justify building a whole new pages for it yet. If we used that rational, we should start building a new page for L1c1 but ignore L1c2 and L1c4. More work needs to be done to develop the L1 page as well. -- Brout8 (talk) 04:40, 18 June 2011 (UTC)[reply]

If you are right, then L2e is West African and no Ethiopian, as Kivisild says: Consistent with figure 7a of Salas et al. (2002), Ethiopian L2b sequences form a subset of a predominantly West African clade, distinguished from West African lineages by a transition at np 16145. In fact, by Salas 2002, L2e (former L2d2) is a West African haplogroup.

There's no information about L1c1 or L1c2 in Wikipedia. Why would someone want to separate them from L1 if nobody has written anything about them. There is no comparison. --Maulucioni (talk) 05:23, 19 June 2011 (UTC)[reply]

The truth is no one really knows where L2e is from. I think they are still making guesses. I only know of one person who is positive for it.

Yes, there is a comparison. There is quite a bit of published research on the subclades of L1c1. There also is already a Haplogroup L1 page just like there is already a Haplogroup L2 page. We don't need to be making loads of new pages on these the subclades. Try to consolidate when you can. These are narrow interest subjects that don’t need new pages. L1c1 and L2a1 are narrow interest subclades. Put anything on the subclades on their respective pages or new articles can be placed as candidates for a merge. --Brout8 (talk) 13:27, 20 June 2011 (UTC)[reply]

Exclamation Mark???

What does the exclamation mark mean "16311!" ? Carstensen (talk) 00:59, 4 February 2015 (UTC)[reply]

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