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Tumor necrosis factor receptor 1

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Template:PBB Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene.[1][2] The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or periodic fever syndrome.[3] Impaired receptor clearance is thought to be a mechanism of the disease.[4] Mutations in the TNFRSF1A gene is associated with elevated risk of multiple sclerosis.[5] Serum levels of TNFRSF1A are elevated in severe mental disorders.[6] [7]. High serum levels is also associated with cognitive impairment and dementia.[8][9]

Interactions

TNFRSF1A has been shown to interact with PSMD2,[10][11] FADD,[12][13] Tumor necrosis factor-alpha,[14][15] BAG4,[16][17] Janus kinase 2,[18] IKK2,[19][20] Caspase 10,[12][21] Janus kinase 1,[18][22] UBE2I,[23] TRPC4AP,[24] PIP4K2B,[25] TRAF2,[13][26][27] RIPK1,[26][28][29][30][31][32] TRADD[13][16][26][27][30][33][34] and Small ubiquitin-related modifier 1.[35][36]

See also

References

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  7. ^ {{cite journal | pmid = 9839997
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