N-acetylgalactosamine kinase

In enzymology, a N-acetylgalactosamine kinase (EC 2.7.1.157) is an enzyme that catalyzes the chemical reaction

ATP + N-acetyl-D-galactosamine $\rightleftharpoons$ ADP + N-acetyl-alpha-D-galactosamine 1-phosphate

Thus, the two substrates of this enzyme are ATP and N-acetyl-D-galactosamine, whereas its two products are ADP and N-acetyl-alpha-D-galactosamine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acetyl-D-galactosamine 1-phosphotransferase. Other names in common use include GALK2, GK2, GalNAc kinase, and N-acetylgalactosamine (GalNAc)-1-phosphate kinase.

References

• Pastuszak I, Drake R, Elbein AD (1996). "Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation". J. Biol. Chem. 271: 20776–82. PMID 8702831.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Pastuszak I, O'Donnell J, Elbein AD (1996). "Identification of the GalNAc kinase amino acid sequence". J. Biol. Chem. 271: 23653–6. PMID 8798585.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Thoden JB, Holden HM (2005). "The molecular architecture of human N-acetyl galactosamine kinase". J. Biol. Chem. PMID 16006554.