Talk:Cannabinol

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Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 16:40, 16 January 2022 (UTC)

Linked study refers to CannabiDIOL, not Cannabinol, as an anti-psychotic and anxiolytic

The paper from the Brazilian Journal of Medical and Biological Research that was used as a reference here refers to cannabidiol, not cannabinol. Therefore, I'm removing the references both to the paper and the conclusions erroneously derived from it. - Pacula 15:42, 20 September 2007 (UTC)

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CBN derived from hemp is legal

CBN is legal as long as it's derived from hemp which is legal under the Agricultural Improvement Act of 2018 (“the 2018 Farm Bill”) 2600:1700:4DC0:6100:515:1510:A712:9806 (talk) 22:48, 29 September 2021 (UTC)

From the Farm Bill, 2018: federal authorities relating to the production and marketing of hemp, defined as "the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta-9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis." Quoting: The 2018 Farm Bill, however, explicitly preserved FDA's authority to regulate products containing cannabis or cannabis-derived compounds under the FD&C Act and section 351 of the Public Health Service Act (PHS Act). FDA treats products containing cannabis or cannabis-derived compounds as it does any other FDA-regulated products — meaning they’re subject to the same authorities and requirements as FDA-regulated products containing any other substance.

There are no FDA-approved products from hemp. CBN derived from hemp (with 0.3% THC or lower) is legal to sell as a cosmetics ingredient or for other purposes not regulated by the FDA, but cannot be sold under federal law as an ingredient in food, dietary supplement, or animal feed. I think this means CBN has no logical commercial outlet, but could be extracted from hemp for research purposes. Zefr (talk) 23:05, 29 September 2021 (UTC)

CBN is mildly psychoactive + binds to the CB1 receptor to produce that activity + has had it's psychoactivity compared to THC

I don't know why you removed the 5 studies and stated the single 1 would be fine and then remove it altogether stating there is not enough evidence. You claimed there are no studies showing CBN binds to the CB1 receptor, but CURRENTLY the Wikipedia for Cannabinol RIGHT NOW, has it's own reference and here is another one also confirming it's psych activity compared to Delta-9-THC. So I have no idea why you would remove my references and not remove that claim if you feel it's false but it's not false, CBN binds to the CB1 receptor and produces a mildly psychoactive effect (compared to THC). https://pubs.acs.org/doi/10.1021/jm970126f 3230 Journal of Medicinal Chemistry, 1997, Vol. 40, No. 20 Rhee et al Please READ the full study and not just the description - "Table 1. Binding of Various Cannabinoids to Cannabinoid Receptors" which marks "CBN (1a) 392.2 ( 53.5 ki NM = CB1)" AND "First, CBN (1a) was compared to ∆9-THC (2a). Under our experimental conditions, CBN was about 2-4 times less potent on binding to either CB1 or CB2, in contrast to the data reported by Munro et al.,9 who found that CBN and ∆9-THC are equipotent on CB2." AND "We found that CBN is about 13 times less potent than ∆9-THC"

https://pubs.acs.org/doi/10.1021/acs.jnatprod.0c00965 American Chemical Society and American Society of Pharmacognosy "Receptor activity for CBN and CBV data is shown in Table 8. CBN binds to both the CB1 and CB2 receptors with 10−100-fold lower activity compared to Δ9 -THC depending on the assay and the tissue source of the receptor."

https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C84510 The United States of America National Institute of Health "Cannabinol exerts minimal affinity for CB1 and has a weak effect on the central nervous system." Gettinglit (talk) 22:55, 29 April 2022 (UTC)

No reason to remove mention of CBNs oxidative byproduct under chemistry

There was no reason to remove mention of CBNs oxidative byproduct under it's chemistry section as it relates to the chemistry of CBN involving it's oxidative degration. https://www.mdpi.com/1420-3049/26/6/1761 If you would like I can create and separate section just for it? Why was this removed? All of these reverts are incredibly unusual as they are clearly properly referenced if you have access to the full study. Gettinglit (talk) 22:55, 29 April 2022 (UTC)

No reason to remove that THC degrades to CBN

There was no reason to remove the fact that THC degrades to CBN through oxidation. https://jpharmsci.org/article/S0022-3549(15)39767-7/pdf https://www.sciencedirect.com/science/article/pii/B9780128200070000052

I understand if you disagree with "primarily through the plant" part but to disagree with that and revert to the previous entry does not make any sense because you put back "However, if cannabis is exposed to air or ultraviolet light (for example, in sunlight) for a prolonged period of time, THCA will convert to cannabinolic acid (CBNA)." which is NOT from flowers synthesis as you removed my entry for. In addition these claims have no references. Can you post a study showing THCA converts to CBNA with air and UV light? I can post a study showing THC converts to CBN with oxidation with 2 references and that gets removed? This does not make any sense. Gettinglit (talk) 22:55, 29 April 2022 (UTC)

References needed for the claim below

"There is usually little CBN in a fresh plant. However, if cannabis is exposed to air or ultraviolet light (for example, in sunlight) for a prolonged period of time, THCA will convert to cannabinolic acid (CBNA). CBN is then formed by decarboxylation of CBNA."

This also would not be formation from the plant as you removed my THC to CBN itself claim for. This would be the result of degration from foreign influences (oxidation/hydrolysis/photodegradation) which is what you removed my additions for. Gettinglit (talk) 00:07, 30 April 2022 (UTC)

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