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'''RU-57073''' is a [[nonsteroidal antiandrogen]] which was never marketed.<ref name="pmid10637363">{{cite journal | vauthors = Singh SM, Gauthier S, Labrie F | title = Androgen receptor antagonists (antiandrogens): structure-activity relationships | journal = Curr. Med. Chem. | volume = 7 | issue = 2 | pages = 211–47 | date = February 2000 | pmid = 10637363 | doi = 10.2174/0929867003375371 | url = }}</ref><ref name="pmid8136296">{{cite journal | vauthors = Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D | title = Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor | journal = J. Steroid Biochem. Mol. Biol. | volume = 48 | issue = 1 | pages = 111–9 | date = January 1994 | pmid = 8136296 | doi = 10.1016/0960-0760(94)90257-7 | url = }}</ref><ref name="pmid15700772">{{cite journal | vauthors = Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M | title = RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia | journal = Pharmazie | volume = 60 | issue = 1 | pages = 8–12 | date = January 2005 | pmid = 15700772 | doi = | url = https://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000001/art00002}}</ref> It shows 163% of the [[affinity (pharmacology)|affinity]] of [[testosterone (medication)|testosterone]] for the [[androgen receptor]] and negligible affinity for other [[steroid hormone receptor]]s.<ref name="pmid10637363" /><ref name="pmid8136296" />
'''RU-57073''' is a [[nonsteroidal antiandrogen]] which was never marketed.<ref name="pmid10637363">{{cite journal | vauthors = Singh SM, Gauthier S, Labrie F | title = Androgen receptor antagonists (antiandrogens): structure-activity relationships | journal = Curr. Med. Chem. | volume = 7 | issue = 2 | pages = 211–47 | date = February 2000 | pmid = 10637363 | doi = 10.2174/0929867003375371 | url = }}</ref><ref name="pmid8136296">{{cite journal | vauthors = Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D | title = Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor | journal = J. Steroid Biochem. Mol. Biol. | volume = 48 | issue = 1 | pages = 111–9 | date = January 1994 | pmid = 8136296 | doi = 10.1016/0960-0760(94)90257-7 | s2cid = 31404295 | url = }}</ref><ref name="pmid15700772">{{cite journal | vauthors = Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M | title = RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia | journal = Pharmazie | volume = 60 | issue = 1 | pages = 8–12 | date = January 2005 | pmid = 15700772 | doi = | url = https://www.ingentaconnect.com/content/govi/pharmaz/2005/00000060/00000001/art00002}}</ref> It shows 163% of the [[affinity (pharmacology)|affinity]] of [[testosterone (medication)|testosterone]] for the [[androgen receptor]] and negligible affinity for other [[steroid hormone receptor]]s.<ref name="pmid10637363" /><ref name="pmid8136296" />


{{Affinities of a selection of androgen ligands at steroid hormone receptors}}
{{Affinities of a selection of androgen ligands at steroid hormone receptors}}

Revision as of 21:12, 7 September 2020

RU-57073
Clinical data
Drug classNonsteroidal antiandrogen
Identifiers
  • 4-[3-(2-Hydroxyethyl)-4,4-dimethyl-5-oxo-2-sulfanylideneimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H14F3N3O2S
Molar mass357.35 g·mol−1
3D model (JSmol)
  • CC1(C(=O)N(C(=S)N1CCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C
  • InChI=1S/C15H14F3N3O2S/c1-14(2)12(23)21(13(24)20(14)5-6-22)10-4-3-9(8-19)11(7-10)15(16,17)18/h3-4,7,22H,5-6H2,1-2H3
  • Key:HNTMVNIRYPJDDJ-UHFFFAOYSA-N

RU-57073 is a nonsteroidal antiandrogen which was never marketed.[1][2][3] It shows 163% of the affinity of testosterone for the androgen receptor and negligible affinity for other steroid hormone receptors.[1][2]

Template:Affinities of a selection of androgen ligands at steroid hormone receptors

See also

References

  1. ^ a b Singh SM, Gauthier S, Labrie F (February 2000). "Androgen receptor antagonists (antiandrogens): structure-activity relationships". Curr. Med. Chem. 7 (2): 211–47. doi:10.2174/0929867003375371. PMID 10637363.
  2. ^ a b Teutsch G, Goubet F, Battmann T, Bonfils A, Bouchoux F, Cerede E, Gofflo D, Gaillard-Kelly M, Philibert D (January 1994). "Non-steroidal antiandrogens: synthesis and biological profile of high-affinity ligands for the androgen receptor". J. Steroid Biochem. Mol. Biol. 48 (1): 111–9. doi:10.1016/0960-0760(94)90257-7. PMID 8136296. S2CID 31404295.
  3. ^ Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis CC, Blume-Peytavi U, Schäfer-Korting M (January 2005). "RU 58841-myristate--prodrug development for topical treatment of acne and androgenetic alopecia". Pharmazie. 60 (1): 8–12. PMID 15700772.


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