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Perls is the author of the online "Living to 100 Life Expectancy Calculator".<ref name="Living to 100 Life Expectancy Calculator">{{cite web|last=Perls|first=Thomas|title=Living to 100 Life Expectancy Calculator|url=http://www.livingto100.com|publisher=Thomas Perls|accessdate=30 December 2013}}</ref> Perls is a prominent critic of "hormone replacement therapy" including growth hormone and testosterone for "anti-aging" and "age-management".<ref name="antiagingquackery">{{cite web|url=http://biomedgerontology.oxfordjournals.org/content/59/7/B682.full.pdf+html|title=Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade—More Dangerous Than Ever|year=2004|publisher=Oxford Press|accessdate=18 November 2013}}</ref> He is author of the website hghwatch.com.<ref name="hghwatch">{{cite web|url=http://hghwatch.com/|title=hghwatch|last=Perls|first=Tom|year=2006|accessdate=1 July 2013}}</ref> and he has testified before the U.S. Congress,<ref name="COGR">{{cite web|url=http://oversight-archive.waxman.house.gov/story.asp?id=1740/|title=Committee holds hearing on myths and facts about human growth hormone, B12, and other substances|year=2008|publisher=U.S. House of Representatives|accessdate=8 November 2013}}</ref> as well as provided written testimony for the U.S. Sentencing Commission regarding illegal distribution of growth hormone for anti-aging.<ref name="USSC">{{cite web|url=http://www.ussc.gov/Meetings_and_Rulemaking/Public_Comment/20080300/Perls_PUBCOM.pdf/|title=Sentencing&nbsp;of&nbsp;human&nbsp;growth&nbsp;hormone&nbsp;offenses|year=2008|publisher=Thomas Perls|accessdate=1 July 2013}}</ref> Perls is the author of several academic articles about the medical misuse and illegal distribution of growth hormone and anabolic steroids, including testosterone, for anti-aging and bodybuilding.<ref name="JAMA2005">{{cite web|url=http://jama.jamanetwork.com/article.aspx?articleid=201730/|title=Provision or Distribution of Growth Hormone for "Antiaging". Clinical and Legal Issues|year=2005|publisher=JAMA|accessdate=18 November 2013}}</ref><ref name="JAMA2008">{{cite web|url=http://jama.jamanetwork.com/article.aspx?articleid=182075/|title=New Developments in the Illegal Provision of Growth Hormone for "Anti-Aging" and Bodybuilding|year=2008|publisher=JAMA|accessdate=18 November 2013}}</ref><ref name="iceberg2009">{{cite journal|url=http://onlinelibrary.wiley.com/doi/10.1002/dta.87/pdf/|title=Growth hormone and anabolic steroids:athletes are the tip of the iceberg=2009|publisher=Wiley Interscience|accessdate=18 November 2013|doi=10.1002/dta.87|volume=1|journal=Drug Testing and Analysis|pages=419–425}}</ref>
Perls is the author of the online "Living to 100 Life Expectancy Calculator".<ref name="Living to 100 Life Expectancy Calculator">{{cite web|last=Perls|first=Thomas|title=Living to 100 Life Expectancy Calculator|url=http://www.livingto100.com|publisher=Thomas Perls|accessdate=30 December 2013}}</ref> Perls is a prominent critic of "hormone replacement therapy" including growth hormone and testosterone for "anti-aging" and "age-management".<ref name="antiagingquackery">{{cite web|url=http://biomedgerontology.oxfordjournals.org/content/59/7/B682.full.pdf+html|title=Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade—More Dangerous Than Ever|year=2004|publisher=Oxford Press|accessdate=18 November 2013}}</ref> He is author of the website hghwatch.com.<ref name="hghwatch">{{cite web|url=http://hghwatch.com/|title=hghwatch|last=Perls|first=Tom|year=2006|accessdate=1 July 2013}}</ref> and he has testified before the U.S. Congress,<ref name="COGR">{{cite web|url=http://oversight-archive.waxman.house.gov/story.asp?id=1740/|title=Committee holds hearing on myths and facts about human growth hormone, B12, and other substances|year=2008|publisher=U.S. House of Representatives|accessdate=8 November 2013}}</ref> as well as provided written testimony for the U.S. Sentencing Commission regarding illegal distribution of growth hormone for anti-aging.<ref name="USSC">{{cite web|url=http://www.ussc.gov/Meetings_and_Rulemaking/Public_Comment/20080300/Perls_PUBCOM.pdf/|title=Sentencing&nbsp;of&nbsp;human&nbsp;growth&nbsp;hormone&nbsp;offenses|year=2008|publisher=Thomas Perls|accessdate=1 July 2013}}</ref> Perls is the author of several academic articles about the medical misuse and illegal distribution of growth hormone and anabolic steroids, including testosterone, for anti-aging and bodybuilding.<ref name="JAMA2005">{{cite web|url=http://jama.jamanetwork.com/article.aspx?articleid=201730/|title=Provision or Distribution of Growth Hormone for "Antiaging". Clinical and Legal Issues|year=2005|publisher=JAMA|accessdate=18 November 2013}}</ref><ref name="JAMA2008">{{cite web|url=http://jama.jamanetwork.com/article.aspx?articleid=182075/|title=New Developments in the Illegal Provision of Growth Hormone for "Anti-Aging" and Bodybuilding|year=2008|publisher=JAMA|accessdate=18 November 2013}}</ref><ref name="iceberg2009">{{cite journal|url=http://onlinelibrary.wiley.com/doi/10.1002/dta.87/pdf/|title=Growth hormone and anabolic steroids:athletes are the tip of the iceberg=2009|publisher=Wiley Interscience|accessdate=18 November 2013|doi=10.1002/dta.87|volume=1|journal=Drug Testing and Analysis|pages=419–425}}</ref>


A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal ''[[Science (journal)|Science]]'' in 2011 due to flawed data.<ref name="nyt">{{cite news|url=http://www.nytimes.com/2011/07/23/science/23retract.html?_r=0|title=Scientists Retract Report on Predicting Longevity|publisher=The New York Times|date=22 July 2011}}</ref><ref name="cbs">{{cite web|url=http://www.cbsnews.com/2100-205_162-20081587.html|title=Big "Oops" Forces Retraction of Longevity Study|publisher=CBS News|date=21 July 2011}}</ref>= The corrected version of the paper was then published in the online journal PlosOne <ref>{{cite journal|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029848#pone-0029848-g010 |title=Genetic Signatures of Exceptional Longevity in Humans |journal=PLOS ONE |date=2012-01-18 |accessdate=2014-07-28 |doi=10.1371/journal.pone.0029848 |volume=7 |pages=e29848}}</ref> and several of the reported associations were replicated in additional studies of centenarians.<ref>{{cite journal|title=Meta-analysis of genetic variants associated with human exceptional longevity |date=2013-08-24 |pmc=3808698 | pmid=24244950 |volume=5 |journal=Aging (Albany NY) |pages=653–61 | last1 = Sebastiani | first1 = P | last2 = Bae | first2 = H | last3 = Sun | first3 = FX | last4 = Andersen | first4 = SL | last5 = Daw | first5 = EW | last6 = Malovini | first6 = A | last7 = Kojima | first7 = T | last8 = Hirose | first8 = N | last9 = Schupf | first9 = N | last10 = Puca | first10 = A | last11 = Perls | first11 = TT | doi=10.18632/aging.100594}}</ref><ref>{{cite journal|url=http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2012.00808.x/full |title=Human longevity and common variations in the LMNA gene: a meta-analysis - Conneely - 2012 - Aging Cell - Wiley Online Library |publisher=Onlinelibrary.wiley.com |date= |accessdate=2014-07-28 |doi=10.1111/j.1474-9726.2012.00808.x |volume=11 |journal=Aging Cell |pages=475–481}}</ref><ref>{{cite journal|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099580#pone-0099580-g001 |title=Genetic Variants in PVRL2-TOMM40-APOE Region Are Associated with Human Longevity in a Han Chinese Population |journal=PLOS ONE |date=2014-06-12 |accessdate=2014-07-28 |doi=10.1371/journal.pone.0099580 |volume=9 |pages=e99580}}</ref><ref>{{cite journal|url=http://link.springer.com/article/10.1007/s11357-013-9593-0 |title=The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts |date=2013-10-28 |accessdate=2014-07-28 |doi=10.1007/s11357-013-9593-0 |volume=36 |journal=AGE |pages=933–943}}</ref>
A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal ''[[Science (journal)|Science]]'' in 2011 due to flawed data.<ref name="nyt">{{cite news|url=http://www.nytimes.com/2011/07/23/science/23retract.html?_r=0|title=Scientists Retract Report on Predicting Longevity|publisher=The New York Times|date=22 July 2011}}</ref><ref name="cbs">{{cite web|url=http://www.cbsnews.com/2100-205_162-20081587.html|title=Big "Oops" Forces Retraction of Longevity Study|publisher=CBS News|date=21 July 2011}}</ref>= The corrected version of the paper was then published in the online journal ''Plos One'' <ref>{{cite journal|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029848#pone-0029848-g010 |title=Genetic Signatures of Exceptional Longevity in Humans |journal=PLOS ONE |date=2012-01-18 |accessdate=2014-07-28 |doi=10.1371/journal.pone.0029848 |volume=7 |pages=e29848}}</ref> and several of the reported associations were replicated in additional studies of centenarians.<ref>{{cite journal|title=Meta-analysis of genetic variants associated with human exceptional longevity |date=2013-08-24 |pmc=3808698 | pmid=24244950 |volume=5 |journal=Aging (Albany NY) |pages=653–61 | last1 = Sebastiani | first1 = P | last2 = Bae | first2 = H | last3 = Sun | first3 = FX | last4 = Andersen | first4 = SL | last5 = Daw | first5 = EW | last6 = Malovini | first6 = A | last7 = Kojima | first7 = T | last8 = Hirose | first8 = N | last9 = Schupf | first9 = N | last10 = Puca | first10 = A | last11 = Perls | first11 = TT | doi=10.18632/aging.100594}}</ref><ref>{{cite journal|url=http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2012.00808.x/full |title=Human longevity and common variations in the LMNA gene: a meta-analysis |date= |accessdate=2014-07-28 |doi=10.1111/j.1474-9726.2012.00808.x |volume=11 |journal=Aging Cell |pages=475–481}}</ref><ref>{{cite journal|url=http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099580#pone-0099580-g001 |title=Genetic Variants in PVRL2-TOMM40-APOE Region Are Associated with Human Longevity in a Han Chinese Population |journal=PLOS ONE |date=2014-06-12 |accessdate=2014-07-28 |doi=10.1371/journal.pone.0099580 |volume=9 |pages=e99580}}</ref><ref>{{cite journal|url=http://link.springer.com/article/10.1007/s11357-013-9593-0 |title=The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts |date=2013-10-28 |accessdate=2014-07-28 |doi=10.1007/s11357-013-9593-0 |volume=36 |journal=AGE |pages=933–943}}</ref>


==References==
==References==

Revision as of 08:31, 21 July 2016

Thomas Perls MD, MPH (born 1960) is the founding director of the New England Centenarian Study.[1] Born in Palo Alto, California, Perls later moved to Colorado and now lives in Boston. He received his B.A. from Pitzer College in 1982, his M.D. from the University of Rochester School of Medicine and Dentistry in 1986 and his M.P.H. from Harvard University in 1993.[2] He is a Principal Investigator of the National Institute on Aging funded Long Life Family Study.[3] Perls is Professor of medicine at Boston University School of Medicine and attending physician in geriatrics at Boston Medical Center. He is author of over 110 peer reviewed articles primarily in the areas of biodemography and genetics of human exceptional longevity.

Perls is the author of the online "Living to 100 Life Expectancy Calculator".[4] Perls is a prominent critic of "hormone replacement therapy" including growth hormone and testosterone for "anti-aging" and "age-management".[5] He is author of the website hghwatch.com.[6] and he has testified before the U.S. Congress,[7] as well as provided written testimony for the U.S. Sentencing Commission regarding illegal distribution of growth hormone for anti-aging.[8] Perls is the author of several academic articles about the medical misuse and illegal distribution of growth hormone and anabolic steroids, including testosterone, for anti-aging and bodybuilding.[9][10][11]

A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal Science in 2011 due to flawed data.[12][13]= The corrected version of the paper was then published in the online journal Plos One [14] and several of the reported associations were replicated in additional studies of centenarians.[15][16][17][18]

References

  1. ^ "The new England Centenarian Study". Boston University. 2002. Retrieved 1 July 2013.
  2. ^ Anderson, Porter (27 August 2001). "Thomas Perls: Longevity researcher". Cable News Network. Retrieved 15 June 2015.
  3. ^ "The Long Life Family Study". Washington University St Louis. 2006. Retrieved 1 July 2013.
  4. ^ Perls, Thomas. "Living to 100 Life Expectancy Calculator". Thomas Perls. Retrieved 30 December 2013.
  5. ^ "Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade—More Dangerous Than Ever". Oxford Press. 2004. Retrieved 18 November 2013.
  6. ^ Perls, Tom (2006). "hghwatch". Retrieved 1 July 2013.
  7. ^ "Committee holds hearing on myths and facts about human growth hormone, B12, and other substances". U.S. House of Representatives. 2008. Retrieved 8 November 2013.
  8. ^ "Sentencing of human growth hormone offenses". Thomas Perls. 2008. Retrieved 1 July 2013.
  9. ^ "Provision or Distribution of Growth Hormone for "Antiaging". Clinical and Legal Issues". JAMA. 2005. Retrieved 18 November 2013.
  10. ^ "New Developments in the Illegal Provision of Growth Hormone for "Anti-Aging" and Bodybuilding". JAMA. 2008. Retrieved 18 November 2013.
  11. ^ "Growth hormone and anabolic steroids:athletes are the tip of the iceberg=2009". Drug Testing and Analysis. 1. Wiley Interscience: 419–425. doi:10.1002/dta.87. Retrieved 18 November 2013.
  12. ^ "Scientists Retract Report on Predicting Longevity". The New York Times. 22 July 2011.
  13. ^ "Big "Oops" Forces Retraction of Longevity Study". CBS News. 21 July 2011.
  14. ^ "Genetic Signatures of Exceptional Longevity in Humans". PLOS ONE. 7: e29848. 2012-01-18. doi:10.1371/journal.pone.0029848. Retrieved 2014-07-28.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  15. ^ Sebastiani, P; Bae, H; Sun, FX; Andersen, SL; Daw, EW; Malovini, A; Kojima, T; Hirose, N; Schupf, N; Puca, A; Perls, TT (2013-08-24). "Meta-analysis of genetic variants associated with human exceptional longevity". Aging (Albany NY). 5: 653–61. doi:10.18632/aging.100594. PMC 3808698. PMID 24244950.
  16. ^ "Human longevity and common variations in the LMNA gene: a meta-analysis". Aging Cell. 11: 475–481. doi:10.1111/j.1474-9726.2012.00808.x. Retrieved 2014-07-28.
  17. ^ "Genetic Variants in PVRL2-TOMM40-APOE Region Are Associated with Human Longevity in a Han Chinese Population". PLOS ONE. 9: e99580. 2014-06-12. doi:10.1371/journal.pone.0099580. Retrieved 2014-07-28.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  18. ^ "The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts". AGE. 36: 933–943. 2013-10-28. doi:10.1007/s11357-013-9593-0. Retrieved 2014-07-28.


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