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NONMEM is a software package developed by Stuart L. Beal and Lewis B. Sheiner in the late 1970s at UCSF for population pharmacokinetic modeling.^[1]^[2]^[3]^[4] Its name is an acronym for non-linear mixed effects modeling and has become the "gold standard"^{[citation needed]}, both in the pharmaceutical industry and academia.

^ Sheiner, Lewis B.; B. Rosenberg; V.V. Marathe (1977). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 5 (5): 445–79. doi:10.1007/BF01061728. PMID 925881.
^ Sheiner, Lewis B.; Stuart L. Beal (1980). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters I. Michaelis-Menten Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 8 (6): 553–71. doi:10.1007/BF01060053.
^ Sheiner, Lewis B.; Stuart L. Beal (1981). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters II. Biexponential Model and Experimental Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 9 (5): 635–51. doi:10.1007/BF01061030.
^ Sheiner, Lewis B.; Stuart L. Beal (1983). "Evaluation of Methods for Estimating Population Pharmacokinetic Parameters III. Monoexponential Model: Routine Clinical Pharmacokinetic Data". Journal of Pharmacokinetics and Biopharmaceutics. 11 (3): 303–19. doi:10.1007/BF01061870.

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 ==External links==
-*[http://www.iconplc.com/technology/products/nonmem/ Product site]
+*[http://www.iconplc.com/innovation/solutions/nonmem/ Product site]
 *[http://www.cognigencorp.com/index.php/cognigen/resources_nonmem NONMEM UsersNet Archive]