Stapled peptide: Difference between revisions
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[[File:4MZK stapled peptide.png|thumb|right|A cartoon depiction of a stapled peptide. The red coloring depicts a helix, and the green coloring denotes the hydrocarbon staple. Rendering based on [[Protein_Data_Bank | PDB]] {{PDB2|4MZK}}.<ref name=pmid25084543>{{cite journal|last1=Douse|first1=CH|last2=Maas|first2=SJ|last3=Thomas|first3=JC|last4=Garnett|first4=JA|last5=Sun|first5=Y|last6=Cota|first6=E|last7=Tate|first7=EW|title=Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.|journal=ACS chemical biology|date=17 October 2014|volume=9|issue=10|pages=2204-9|pmid=25084543|accessdate=22 July 2015}}</ref>]] |
[[File:4MZK stapled peptide.png|thumb|right|A cartoon depiction of a stapled peptide. The red coloring depicts a helix, and the green coloring denotes the hydrocarbon staple. Rendering based on [[Protein_Data_Bank | PDB]] {{PDB2|4MZK}}.<ref name=pmid25084543>{{cite journal|last1=Douse|first1=CH|last2=Maas|first2=SJ|last3=Thomas|first3=JC|last4=Garnett|first4=JA|last5=Sun|first5=Y|last6=Cota|first6=E|last7=Tate|first7=EW|title=Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.|journal=ACS chemical biology|date=17 October 2014|volume=9|issue=10|pages=2204-9|pmid=25084543|accessdate=22 July 2015}}</ref>]] |
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A '''stapled peptide''' is a [[peptide]] that has a synthetic brace ("staple"). Tandem staples on a peptide are sometimes referred to as '''stitched peptides'''.<ref name=pmid22230563>{{cite journal|last1=Verdine|first1=GL|last2=Hilinski|first2=GJ|title=Stapled peptides for intracellular drug targets.|journal=Methods in enzymology|date=2012|volume=503|pages=3-33|pmid=22230563|accessdate=22 July 2015}}</ref> Peptide stapling is used to enhance [[pharmacologic]] performance of peptides.<ref name=pmid22230563> |
A '''stapled peptide''' is a [[peptide]] that has a synthetic brace ("staple"). Tandem staples on a peptide are sometimes referred to as '''stitched peptides'''.<ref name=pmid22230563>{{cite journal|last1=Verdine|first1=GL|last2=Hilinski|first2=GJ|title=Stapled peptides for intracellular drug targets.|journal=Methods in enzymology|date=2012|volume=503|pages=3-33|pmid=22230563|accessdate=22 July 2015}}</ref> Peptide stapling is used to enhance [[pharmacologic]] performance of peptides.<ref name=pmid22230563></ref> |
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==References== |
==References== |
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Revision as of 04:03, 22 July 2015
A stapled peptide is a peptide that has a synthetic brace ("staple"). Tandem staples on a peptide are sometimes referred to as stitched peptides.[2] Peptide stapling is used to enhance pharmacologic performance of peptides.[2]
References
- ^ Douse, CH; Maas, SJ; Thomas, JC; Garnett, JA; Sun, Y; Cota, E; Tate, EW (17 October 2014). "Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction". ACS chemical biology. 9 (10): 2204–9. PMID 25084543.
{{cite journal}}:|access-date=requires|url=(help) - ^ a b Verdine, GL; Hilinski, GJ (2012). "Stapled peptides for intracellular drug targets". Methods in enzymology. 503: 3–33. PMID 22230563.
{{cite journal}}:|access-date=requires|url=(help)