Tom Perls: Difference between revisions
please do not remove references that come from major media sources |
problem was never really corrected, they just published in a journal that accepts just about anything. It is rare to be retracted from Science, so this needs to stay |
||
| Line 5: | Line 5: | ||
Dr. Perls' primary area of clinical research is the clinical characteristics and biodemographic and genetic determinants of exceptional longevity. The New England Centenarian Study, which he has led since 1995, is the largest study of centenarians and their family members in the world, with an enrollment of over 2000 centenarians and over 140 supercentenarians (people age 110+ years). Important findings to-date include (1) exceptional longevity runs strongly in families, (2) there is a correlation between natural advanced maternal age and survival beyond 100 years, (3) the prevalence of age-related diseases (morbidity) and disability are markedly compressed into the past few years of life in people who survive to 105+ years, even more so, 110+ years, thus supporting the "Compression of Morbidity Hypothesis", (4) the genetic component of survival increases with ages beyond approximately 100 years, (5) exceptional longevity is a complex trait involving many genetic variants that individually have weak effects, but as a group can have a very strong effect especially for those surviving beyond age 107+ years.<ref name="plos">{{cite web|url=http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029848|title=Genetic signatures of exceptional longevity in humans|publisher=PLOS|date=18 January 2012}}</ref> |
Dr. Perls' primary area of clinical research is the clinical characteristics and biodemographic and genetic determinants of exceptional longevity. The New England Centenarian Study, which he has led since 1995, is the largest study of centenarians and their family members in the world, with an enrollment of over 2000 centenarians and over 140 supercentenarians (people age 110+ years). Important findings to-date include (1) exceptional longevity runs strongly in families, (2) there is a correlation between natural advanced maternal age and survival beyond 100 years, (3) the prevalence of age-related diseases (morbidity) and disability are markedly compressed into the past few years of life in people who survive to 105+ years, even more so, 110+ years, thus supporting the "Compression of Morbidity Hypothesis", (4) the genetic component of survival increases with ages beyond approximately 100 years, (5) exceptional longevity is a complex trait involving many genetic variants that individually have weak effects, but as a group can have a very strong effect especially for those surviving beyond age 107+ years.<ref name="plos">{{cite web|url=http://www.plosone.org/article/info:doi/10.1371/journal.pone.0029848|title=Genetic signatures of exceptional longevity in humans|publisher=PLOS|date=18 January 2012}}</ref> |
||
A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal [[Science]] in 2011 due to flawed data.<ref name="nyt">{{cite web|url=http://www.nytimes.com/2011/07/23/science/23retract.html?_r=0|title=Scientists Retract Report on Predicting Longevity|publisher=The New York Times|date=22 July 2011|}}</ref><ref name="cbs">{{cite web|url=http://www.cbsnews.com/2100-205_162-20081587.html|title=Big "Oops" Forces Retraction of Longevity Study|publisher=CBS News|date=21 July 2011}}</ref> |
A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal [[Science]] in 2011 due to flawed data.<ref name="nyt">{{cite web|url=http://www.nytimes.com/2011/07/23/science/23retract.html?_r=0|title=Scientists Retract Report on Predicting Longevity|publisher=The New York Times|date=22 July 2011|}}</ref><ref name="cbs">{{cite web|url=http://www.cbsnews.com/2100-205_162-20081587.html|title=Big "Oops" Forces Retraction of Longevity Study|publisher=CBS News|date=21 July 2011}}</ref> |
||
Revision as of 23:11, 27 July 2014
Thomas Perls MD, MPH (born 1960) is the founding director of the New England Centenarian Study.[1] Born in Palo Alto, California, Perls later moved to Colorado and is now residing in Boston. He received his B.A. from Pitzer College in 1982, his M.D. from the University of Rochester School of Medicine and Dentistry in 1986 and his M.P.H. from Harvard University in 1993. Dr. Perls graduated from the Harbor UCLA Medical Center Internal Medicine program in 1989 and a 3 year Geriatrics clinical and research Geriatrics fellowship at the Harvard Medical School Division on Aging in 1993. He is board certified in Internal Medicine with additional qualifications in Geriatrics. He is also a Fellow of the American College of Physicians. [2] He is a Principal Investigator of the National Institute on Aging funded Long Life Family Study.[3] Dr Perls is Professor of medicine at Boston University School of Medicine and attending physician in geriatrics at Boston Medical Center. He is author of over 110 peer reviewed articles primarily in the areas of biodemography and genetics of human exceptional longevity as well as anti-aging quackery.
Dr. Perls is the author of the online Living to 100 Life Expectancy Calculator.[4] Perls is a prominent critic of "hormone replacement therapy" including growth hormone and testosterone for "anti-aging" and "age-management".[5] He is author of the website hghwatch.com.[6] and he has testified before the U.S. Congress.[7] as well as provided written testimony for the U.S. Sentencing Commission regarding illegal distribution of growth hormone for anti-aging.[8] Dr. Perls is an author of several academic articles about the medical misuse and illegal distribution of growth hormone and anabolic steroids, including testosterone, for anti-aging and bodybuilding.[9][10][11]
Dr. Perls' primary area of clinical research is the clinical characteristics and biodemographic and genetic determinants of exceptional longevity. The New England Centenarian Study, which he has led since 1995, is the largest study of centenarians and their family members in the world, with an enrollment of over 2000 centenarians and over 140 supercentenarians (people age 110+ years). Important findings to-date include (1) exceptional longevity runs strongly in families, (2) there is a correlation between natural advanced maternal age and survival beyond 100 years, (3) the prevalence of age-related diseases (morbidity) and disability are markedly compressed into the past few years of life in people who survive to 105+ years, even more so, 110+ years, thus supporting the "Compression of Morbidity Hypothesis", (4) the genetic component of survival increases with ages beyond approximately 100 years, (5) exceptional longevity is a complex trait involving many genetic variants that individually have weak effects, but as a group can have a very strong effect especially for those surviving beyond age 107+ years.[12]
A controversial paper regarding the genetics of aging with which Perls was associated was retracted from the journal Science in 2011 due to flawed data.[13][14]
References
- ^ "The new England Centenarian Study". Boston University. 2002. Retrieved 1 July 2013.
- ^ Anderson, Porter (27 August 2001). "Thomas Perls: Longevity researcher". Cable News Network. Retrieved 1 July 2010.
{{cite news}}: Check date values in:|year=/|date=mismatch (help) - ^ "The Long Life Family Study". Washington University St Louis. 2006. Retrieved 1 July 2013.
- ^ Perls, Thomas. "Living to 100 Life Expectancy Calculator". Thomas Perls. Retrieved 30 December 2013.
- ^ "Anti-Aging Quackery: Human Growth Hormone and Tricks of the Trade—More Dangerous Than Ever". Oxford Press. 2004. Retrieved 1 8 November 2013.
{{cite web}}: Check date values in:|accessdate=(help) - ^ Perls, Tom (2006). "hghwatch". Retrieved 1 July 2013.
- ^ "Committee holds hearing on myths and facts about human growth hormone, B12, and other substances". U.S. House of Repreentatives. 2008. Retrieved 8 November 2013.
- ^ "Sentencing of human growth hormone offenses". Thomas Perls. 2008. Retrieved 1 July 2013.
{{cite web}}: no-break space character in|title=at position 11 (help) - ^ "Provision or Distribution of Growth Hormone for "Antiaging". Clinical and Legal Issues". JAMA. 2005. Retrieved 1 8 November 2013.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "New Developments in the Illegal Provision of Growth Hormone for "Anti-Aging" and Bodybuilding". JAMA. 2008. Retrieved 1 8 November 2013.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Growth hormone and anabolic steroids:athletes are the tip of the iceberg=2009". Wiley Interscience. Retrieved 1 8 November 2013.
{{cite web}}: Check date values in:|accessdate=(help) - ^ "Genetic signatures of exceptional longevity in humans". PLOS. 18 January 2012.
- ^ "Scientists Retract Report on Predicting Longevity". The New York Times. 22 July 2011.
{{cite web}}: Cite has empty unknown parameter:|1=(help) - ^ "Big "Oops" Forces Retraction of Longevity Study". CBS News. 21 July 2011.
  | This biography of an American academic is a stub. You can help Wikipedia by expanding it. |