77-LH-28-1: Difference between revisions

77-LH-28-1
Names
	IUPAC name 1-[3-(4-Butyl-1-piperidinyl)propyl]-3,4-dihydro-2(1H)-quinolinone
Identifiers
CAS Number	560085-11-2 ;
3D model (JSmol)	Interactive image;
ChemSpider	8412246 ;
PubChem CID	10236758;
CompTox Dashboard (EPA)	DTXSID90437063 ;
	InChI InChI=1S/C21H32N2O/c1-2-3-7-18-12-16-22(17-13-18)14-6-15-23-20-9-5-4-8-19(20)10-11-21(23)24/h4-5,8-9,18H,2-3,6-7,10-17H2,1H3 Key: PHMGZAICAOYEAF-UHFFFAOYSA-N ;
	SMILES O=C2N(c1ccccc1CC2)CCCN3CCC(CC3)CCCC;
Properties
Chemical formula	C21H32N2O
Molar mass	328.500 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

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Revision as of 14:36, 19 December 2013

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M₁) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M₁ over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood brain barrier and is therefore a useful pharmocologic tool with cognition enhancing effects.^[1]

References

^ C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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[1] C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.{{cite journal}}: CS1 maint: multiple names: authors list (link)

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-'''77-LH-28-1''' is a recently discovered selective [[agonist]] of [[muscarinic acetylcholine receptor]] subtype 1 ([[muscarinic acetylcholine receptor M1|M<sub>1</sub>]]). It is an [[allosteric]] agonist, exhibiting over 100-fold specificity for M<sub>1</sub> over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the [[blood brain barrier]] and is therefore a useful pharmocologic tool with cognition enhancing effects.<ref>{{cite journal | doi = 10.1038/bjp.2008.152 | author = C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson | title = Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1 | journal = Br J Pharmacol. | year = 2008 | volume = 154 | issue = 5 | pages = 1104–1115 | pmid = 18454168 | pmc = 2451039}} </ref>
+'''77-LH-28-1''' is a selective [[agonist]] of [[muscarinic acetylcholine receptor]] subtype 1 ([[muscarinic acetylcholine receptor M1|M<sub>1</sub>]]) discovered in 2008. It is an [[allosteric]] agonist, exhibiting over 100-fold specificity for M<sub>1</sub> over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the [[blood brain barrier]] and is therefore a useful pharmocologic tool with cognition enhancing effects.<ref>{{cite journal|doi=10.1038/bjp.2008.152|author=C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson|title= Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1|journal=Br J Pharmacol|year=2008|volume= 154|issue=5|pages=1104–1115|pmid=18454168|pmc=2451039}} </ref>
-== References ==
+==References==
 {{Reflist}}