Interleukin-7 receptor: Difference between revisions
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== Function == |
== Function == |
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Interleukin-7 receptor has been shown to play a critical role in the V(D)J recombination |
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as [[V(D)J recombination]]. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).<ref name="entrez">{{cite web | title = Entrez Gene: IL7R interleukin 7 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575| accessdate = }}</ref> |
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== Diseases == |
== Diseases == |
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Revision as of 16:51, 5 September 2011
Template:Signaltransduction-stub
| Interleukin-7 receptor-α | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | IL7R | ||||||
| Alt. symbols | CD127 | ||||||
| NCBI gene | 3575 | ||||||
| HGNC | 6024 | ||||||
| OMIM | 146661 | ||||||
| RefSeq | NM_002185 | ||||||
| UniProt | P16871 | ||||||
| Other data | |||||||
| Locus | Chr. 5 p13 | ||||||
| |||||||
| interleukin 2 receptor, gamma | |||||||
|---|---|---|---|---|---|---|---|
 | |||||||
| Identifiers | |||||||
| Symbol | IL2RG | ||||||
| Alt. symbols | SCIDX1, IMD4, CD132 | ||||||
| NCBI gene | 3561 | ||||||
| HGNC | 6010 | ||||||
| OMIM | 308380 | ||||||
| RefSeq | NM_000206 | ||||||
| UniProt | P31785 | ||||||
| Other data | |||||||
| Locus | Chr. X q13 | ||||||
| |||||||
The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α, CD127, and common-γ chain receptor, CD132.[2] [3] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15. Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.
Function
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[4]
Diseases
Several diseases are associated with Interleukin-7 receptor including multiple sclerosis,[5] rheumatoid arthritis and juvenile idiopathic arthritis.[6]
See also
References
- ^ PDB: 2B5IWang X, Rickert M, Garcia KC (2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 (5751): 1159–63. doi:10.1126/science.1117893. PMID 16293754.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Noguchi M, Nakamura Y, Russell SM; et al. (1994). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ *Kroemer RT, Richards WG (1997). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926.
- ^ "Entrez Gene: IL7R interleukin 7 receptor".
- ^ Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet. 39 (9): 1083–91. doi:10.1038/ng2103. PMID 17660817.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens. 74 (5): 429–31. doi:10.1111/j.1399-0039.2009.01342.x. PMID 19744146.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
External links
- IL7R+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.