Small nucleolar RNA SNORA77: Difference between revisions
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'''Small nucleolar RNA SNORA77''' (also known as ACA63) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifiying RNA is located in the nucleolus of the [[eukaryotic]] cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA). |
'''Small nucleolar RNA SNORA77''' (also known as ACA63) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifiying RNA is located in the nucleolus of the [[eukaryotic]] cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA). |
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SNORA77 was identified by computational screening and its expression in mouse experimentally verified by [[Northern blot]] and primer extension analysis<ref name="pmid16373490">{{cite journal | author = Schattner P, Barberan-Soler S, Lowe TM | title = A computational screen for mammalian pseudouridylation guide H/ACA RNAs | journal = RNA | volume = 12 | issue = 1 | pages = 15–25 | year = 2006 | pmid = 16373490 | doi = 10.1261/rna.2210406 | issn = }}</ref>. It belongs to the [[SnoRNA#H.2FACA box|H/ACA box]] class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and conserved H/ACA-box motifs <ref name="pmid15199136">{{cite journal | author = Kiss AM, Jady BE, Bertrand E, Kiss T | title = Human box H/ACA pseudouridylation guide RNA machinery | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = |
SNORA77 was identified by computational screening and its expression in mouse experimentally verified by [[Northern blot]] and primer extension analysis<ref name="pmid16373490">{{cite journal | author = Schattner P, Barberan-Soler S, Lowe TM | title = A computational screen for mammalian pseudouridylation guide H/ACA RNAs | journal = RNA | volume = 12 | issue = 1 | pages = 15–25 | year = 2006 | pmid = 16373490 | doi = 10.1261/rna.2210406 | issn = }}</ref>. It belongs to the [[SnoRNA#H.2FACA box|H/ACA box]] class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and conserved H/ACA-box motifs <ref name="pmid15199136">{{cite journal | author = Kiss AM, Jady BE, Bertrand E, Kiss T | title = Human box H/ACA pseudouridylation guide RNA machinery | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = 5797–807 | year = 2004 | pmid = 15199136 | doi = 10.1128/MCB.24.13.5797-5807.2004 | issn = }}</ref>. |
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SNORA77 is proposed to guide the pseudouridylation of 18S [[ribosomal RNA]] (rRNA) residue U814<ref name="pmid16381836">{{cite journal | author = Lestrade L, Weber MJ | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D158–62 | year = 2006 | pmid = 16381836 | doi = 10.1093/nar/gkj002 | issn = }}</ref>. Pseudouridylation is the ([[isomerisation]] of the nucleoside [[uridine]]) to the different isomeric form [[pseudouridine]]. |
SNORA77 is proposed to guide the pseudouridylation of 18S [[ribosomal RNA]] (rRNA) residue U814<ref name="pmid16381836">{{cite journal | author = Lestrade L, Weber MJ | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D158–62 | year = 2006 | pmid = 16381836 | doi = 10.1093/nar/gkj002 | issn = }}</ref>. Pseudouridylation is the ([[isomerisation]] of the nucleoside [[uridine]]) to the different isomeric form [[pseudouridine]]. |
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Revision as of 14:10, 9 June 2008
| Small nucleolar RNA SNORA77 | |
|---|---|
| Identifiers | |
| Other data | |
| PDB structures | PDBe |
Small nucleolar RNA SNORA77 (also known as ACA63) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifiying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).
SNORA77 was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis[1]. It belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and conserved H/ACA-box motifs [2].
SNORA77 is proposed to guide the pseudouridylation of 18S ribosomal RNA (rRNA) residue U814[3]. Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.
References
- ^ Schattner P, Barberan-Soler S, Lowe TM (2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMID 16373490.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kiss AM, Jady BE, Bertrand E, Kiss T (2004). "Human box H/ACA pseudouridylation guide RNA machinery". Mol. Cell. Biol. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lestrade L, Weber MJ (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Res. 34 (Database issue): D158–62. doi:10.1093/nar/gkj002. PMID 16381836.
External links
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