Whole blood: Difference between revisions
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{{Short description|Unseparated donated human blood}} |
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{{Infobox drug |
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| image = BloodDonationRedCross.jpg |
| image = BloodDonationRedCross.jpg |
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| caption = A [[Red Cross]] whole blood donation |
| caption = A [[Red Cross]] whole blood donation |
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| pregnancy_AU = <!-- A/B1/B2/B3/C/D/X --> |
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| routes_of_administration = IV |
| routes_of_administration = IV |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| ATC_prefix = B05 |
| ATC_prefix = B05 |
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| ATC_suffix = A |
| ATC_suffix = A |
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<!-- Definition and medical uses --> |
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'''Whole blood''' ('''WB''') is human [[blood]] from a standard [[blood donation]].<ref name=Hill2007/> It is used in the treatment of [[massive hemorrhage|massive bleeding]], in [[exchange transfusion]], and when people [[Autotransplantation#Autologous blood donation|donate blood to themselves]]. |
'''Whole blood''' ('''WB''') is human [[blood]] from a standard [[blood donation]].<ref name=Hill2007/> It is used in the treatment of [[massive hemorrhage|massive bleeding]], in [[exchange transfusion]], and when people [[Autotransplantation#Autologous blood donation|donate blood to themselves]].<ref name=Hill2007>{{cite book| vauthors = Hess JR, Beyer GM | chapter = Red Blood Cell Metabolism During Storage: Basic Principles and Practical Aspects | veditors = Hillyer CD |title=Blood Banking and Transfusion Medicine: Basic Principles & Practice|date=2007|publisher=Elsevier Health Sciences|isbn=978-0443069819 |page=190| chapter-url = https://books.google.com/books?id=3QwXx_enKbcC&pg=PT211|language=en|url-status=live|archive-url=https://web.archive.org/web/20170112182648/https://books.google.ca/books?id=3QwXx_enKbcC&pg=PT211|archive-date=2017-01-12}}</ref><ref name=Con2016/> One unit of whole blood (approximately 450 mL) brings up [[hemoglobin]] levels by about 10 g/L.<ref name=Plu2007/><ref>{{cite book | vauthors = Woodson LC, Sherwood ER, Kinsky MP, Talon M, Martinello C, Woodson SM | chapter = Anesthesia for burned patients | veditors = Herndon DN |title=Total Burn Care: Expert Consult - Online and Print |date=2012 |publisher=Elsevier Health Sciences |isbn=9781455737970 |page=194 | chapter-url = https://books.google.com/books?id=Ominwb2istoC&pg=PA194 |language=en}}</ref> [[Cross matching]] is typically done before the blood is given.<ref name=Con2016/><ref name=Ba2016/> It is given by [[intravenous|injection into a vein]].<ref>{{cite book| vauthors = Flagg C | chapter = Intravenous Therapy | veditors = Linton AD |title=Introduction to Medical-Surgical Nursing|date=2015|publisher=Elsevier Health Sciences|isbn=9781455776412 |page=287 | chapter-url= https://books.google.com/books?id=mi3uBgAAQBAJ&pg=PA287 |language=en|url-status=live|archive-url= https://web.archive.org/web/20170914035128/https://books.google.ca/books?id=mi3uBgAAQBAJ&pg=PA287|archive-date=2017-09-14}}</ref> |
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<!-- Side effects and mechanism --> |
<!-- Side effects and mechanism --> |
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Side effects include [[ |
Side effects include [[Hemolytic transfusion reaction|red blood cell breakdown]], [[high blood potassium]], [[Transfusion transmitted infection|infection]], [[Transfusion associated circulatory overload|volume overload]], [[transfusion related acute lung injury|lung injury]], and [[Allergic transfusion reaction|allergic reactions]] such as [[anaphylaxis]].<ref name="Con2016" /><ref name="Plu2007" /> Whole blood is made up of [[red blood cells]], [[white blood cells]], [[platelets]], and [[blood plasma]].<ref name=Plu2007/> It is best within a day of collection; however, can be used for up to three weeks.<ref name=Plu2007>{{cite book| vauthors = Plumer AL | chapter = Transfusion Therapy |title=Plumer's Principles and Practice of Intravenous Therapy |date=2007|publisher=Lippincott Williams & Wilkins|isbn=9780781759441|page=422| chapter-url=https://books.google.com/books?id=VtybuvktyWkC&pg=PA422|language=en|url-status=live|archive-url=https://web.archive.org/web/20170112180236/https://books.google.ca/books?id=VtybuvktyWkC&pg=PA422|archive-date=2017-01-12}}</ref><ref name=Ba2016/><ref>{{cite book| chapter = Blood Conservation and Transfusion | vauthors = Marini JF, Wheeler AP |title=Critical Care Medicine: The Essentials|date=2012|publisher=Lippincott Williams & Wilkins|isbn=9781451152845|page=267|edition=4th | chapter-url = https://books.google.com/books?id=pD24mJE9Rh4C&pg=PA267|language=en|url-status=live|archive-url=https://web.archive.org/web/20170111000331/https://books.google.ca/books?id=pD24mJE9Rh4C&pg=PA267|archive-date=2017-01-11}}</ref> The blood is typically combined with an [[anticoagulant]] and [[preservative]] during the collection process.<ref>{{cite book| vauthors = | chapter = Donor Screening and Blood Collection | veditors = Rudmann SV |title=Textbook of Blood Banking and Transfusion Medicine|date=2005|publisher=Elsevier Health Sciences|isbn=072160384X|page=205| chapter-url = https://books.google.com/books?id=dXdISwJQJFIC&pg=PA205|language=en|url-status=live|archive-url=https://web.archive.org/web/20170112184139/https://books.google.ca/books?id=dXdISwJQJFIC&pg=PA205|archive-date=2017-01-12}}</ref> |
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<!-- History, society and culture --> |
<!-- History, society and culture --> |
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The first transfusion of whole blood was in 1818; however, common use did not begin until the [[First World War|First]] and [[Second World War]]s.<ref name=Ba2016>{{cite journal| |
The first transfusion of whole blood was in 1818; however, common use did not begin until the [[First World War|First]] and [[Second World War]]s.<ref name=Ba2016>{{cite journal | vauthors = Bahr MP, Yazer MH, Triulzi DJ, Collins RA | title = Whole blood for the acutely haemorrhaging civilian trauma patient: a novel idea or rediscovery? | journal = Transfusion Medicine | volume = 26 | issue = 6 | pages = 406–414 | date = December 2016 | pmid = 27357229 | doi = 10.1111/tme.12329 | s2cid = 24552025 }}</ref><ref>{{cite book| vauthors = Tanaka K | chapter = Transfusion and Coagulation Therapy | veditors = Hemmings HC, Egan TD |title=Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application|date=2012|publisher=Elsevier Health Sciences|isbn=978-1455737932 |page=628 |chapter-url= https://books.google.com/books?id=am_DS7rgypAC&pg=PA628 |language=en|url-status=live|archive-url= https://web.archive.org/web/20170111001826/https://books.google.ca/books?id=am_DS7rgypAC&pg=PA628 |archive-date=2017-01-11}}</ref> It is on the [[WHO Model List of Essential Medicines|World Health Organization's List of Essential Medicines]].<ref name="WHO23rd">{{cite book | vauthors = ((World Health Organization)) | title = The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) | year = 2023 | hdl = 10665/371090 | author-link = World Health Organization | publisher = World Health Organization | location = Geneva | id = WHO/MHP/HPS/EML/2023.02 | hdl-access=free }}</ref> In the 1980s the cost of whole blood was about US$50 per unit in the United States.<ref>{{cite book | chapter = Introduction and Summary |title=Blood policy & technology.|date=1985|publisher=DIANE Publishing|isbn=9781428923331|page=8| chapter-url=https://books.google.com/books?id=D9oirqPhCpwC&pg=PA8|language=en|url-status=live|archive-url=https://web.archive.org/web/20170112185912/https://books.google.ca/books?id=D9oirqPhCpwC&pg=PA8|archive-date=2017-01-12}}</ref> Whole blood is not commonly used outside of the [[developing world]] and [[military]].<ref name=Con2016>{{cite journal | vauthors = Connell NT | title = Transfusion Medicine | journal = Primary Care | volume = 43 | issue = 4 | pages = 651–659 | date = December 2016 | pmid = 27866583 | doi = 10.1016/j.pop.2016.07.004 }}</ref> It is used to make a number of [[blood products]] including [[packed red blood cells]], [[platelet concentrate]], [[cryoprecipitate]], and [[fresh frozen plasma]].<ref name=Hill2007/> |
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==Medical use== |
==Medical use== |
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Whole blood has similar risks to a transfusion of red blood cells and must be [[cross-match]]ed to avoid hemolytic [[transfusion reaction]]s. Most of the reasons for use are the same as those for RBCs, and whole blood is not frequently used in high income countries where packed red blood cells are readily available.<ref name=":0" /><ref name=":1">{{cite journal | vauthors = Pivalizza EG, Stephens CT, Sridhar S, Gumbert SD, Rossmann S, Bertholf MF, Bai Y, Cotton BA | display-authors = 6 | title = Whole Blood for Resuscitation in Adult Civilian Trauma in 2017: A Narrative Review | journal = Anesthesia and Analgesia | volume = 127 | issue = 1 | pages = 157–162 | date = July 2018 | pmid = 29771715 | doi = 10.1213/ANE.0000000000003427 | s2cid = 21697290 | doi-access = free }}</ref> However, use of whole blood is much more common in low and middle income countries. Over 40% of blood collected in low-income countries is administered as whole blood, and approximately a third of all blood collected in middle-income countries is administered as whole blood.<ref>{{Cite web|url=https://www.who.int/news-room/fact-sheets/detail/blood-safety-and-availability|title=Blood safety and availability|website=www.who.int|language=en|access-date=2019-06-22}}</ref> |
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Whole blood has similar risks to a transfusion of red blood cells and must be [[cross-match]]ed to avoid hemolytic [[transfusion reaction]]s. Most of the indications for use are identical to those for RBCs, and whole blood is not used{{clarify|date=October 2017}} because the extra plasma can contribute to [[transfusion associated circulatory overload]] (TACO), a potentially dangerous complication. |
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Whole blood is sometimes "recreated" from stored red blood cells and [[fresh frozen plasma]] (FFP) for neonatal transfusions. This is done to provide a final product with a very specific hematocrit (percentage of red cells) with [[ABO|type O]] red cells and [[ABO|type AB]] plasma to minimize the chance of complications. |
Whole blood is sometimes "recreated" from stored [[Packed red blood cells|red blood cells]] and [[fresh frozen plasma]] (FFP) for neonatal transfusions. This is done to provide a final product with a very specific [[hematocrit]] (percentage of red cells) with [[ABO|type O]] red cells and [[ABO|type AB]] plasma to minimize the chance of complications.<ref>Sharma DC, Rai S, Mehra A, Kaur MM, Sao S, Gaur A, Sapra R. Study of 25 cases of exchange transfusion by reconstituted blood in hemolytic disease of newborn. Asian J Transfus Sci. 2007 Jul;1(2):56-8. doi: 10.4103/0973-6247.33448. PMID: 21938234; PMCID: PMC3168121.</ref> |
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Transfusion of whole blood is being used in the military setting and is being studied in pre-hospital trauma care and in the setting of [[massive transfusion]] in the civilian setting.<ref>{{cite journal | |
Transfusion of whole blood is being used in the military setting and is being studied in pre-hospital trauma care and in the setting of [[massive transfusion]] in the civilian setting.<ref name=":0">{{cite journal | vauthors = Flint AW, McQuilten ZK, Wood EM | title = Massive transfusions for critical bleeding: is everything old new again? | journal = Transfusion Medicine | volume = 28 | issue = 2 | pages = 140–149 | date = April 2018 | pmid = 29607593 | doi = 10.1111/tme.12524 | s2cid = 4561424 }}</ref><ref>{{Cite web|url=https://rdcr.org/research/blood-far-forward/|title=Blood Far Forward|website=THOR|language=en-US|access-date=2019-06-22}}</ref><ref>{{cite journal | vauthors = Goforth CW, Tranberg JW, Boyer P, Silvestri PJ | title = Fresh Whole Blood Transfusion: Military and Civilian Implications | journal = Critical Care Nurse | volume = 36 | issue = 3 | pages = 50–57 | date = June 2016 | pmid = 27252101 | doi = 10.4037/ccn2016780 }}</ref><ref name=":1" /> |
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Whole blood can be ABO-type specific when the recipient blood type is known. For unknown recipient type, low-titer O universal donor whole blood (LTOWB) can be used; this requires that the donor plasma contains only low titers of anti-A and anti-B.<ref>Milford EM, Gurney JM, Beckett A, Strandenes G, Reade MC. Type-specific whole blood still has a role in the era of low titer O universal donor transfusion for severe trauma hemorrhage. J Trauma Acute Care Surg. 2024 May 20. doi: 10.1097/TA.0000000000004369. Epub ahead of print. PMID: 38764142.</ref> |
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==Processing== |
==Processing== |
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Historically, blood was [[Blood transfusion|transfused]] as whole blood without further processing. Most [[blood banks]] now split the whole blood into two or more components,<ref name="HillyerShaz2009">{{cite book| |
Historically, blood was [[Blood transfusion|transfused]] as whole blood without further processing. Most [[blood banks]] now split the whole blood into two or more components,<ref name="HillyerShaz2009">{{cite book| vauthors = Greene CE, Hillyer CD | chapter = Component preparation and manufacturing | veditors = Hillyer CD, Shaz BH, Zimring JC, Abshire TC |title=Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects| chapter-url= https://books.google.com/books?id=cGBaz0hp_fcC&pg=PA45|access-date=16 November 2010|date=17 June 2009 |publisher =Elsevier|isbn=978-0-12-374432-6|pages=45–|url-status=live|archive-url= https://web.archive.org/web/20170923233148/https://books.google.com/books?id=cGBaz0hp_fcC&pg=PA45 |archive-date=23 September 2017}}</ref> typically [[red blood cells]] and a [[blood plasma|plasma]] component such as [[fresh frozen plasma]]. [[Platelets]] for transfusion can also be prepared from a unit of whole blood. Some blood banks have replaced this with platelets collected by [[plateletpheresis]] because whole blood platelets, sometimes called "random donor" platelets, must be pooled from multiple donors to get enough for an adult therapeutic dose.<ref>Chu YH, Rose WN, Nawrot W, Raife TJ. Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology. J Int Med Res. 2021 May;49(5):3000605211016748. doi: 10.1177/03000605211016748. PMID: 34013757; PMCID: PMC8142527.</ref> |
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The collected blood is generally separated into components by one of three methods. A centrifuge can be used in a "hard spin" which separates whole blood into plasma and red cells or |
The collected blood is generally separated into components by one of three methods. A centrifuge can be used in a "hard spin" which separates whole blood into plasma and red cells or a "soft spin" which separates it into plasma, buffy coat (used to make platelets), and red blood cells. The third method is sedimentation: the blood simply sits overnight and the red cells and plasma are separated by gravitational interactions. Preparing a pooled buffy coat concentrate may provide additional advantages.<ref>Kumar R, Dhawan HK, Sharma RR, Kaur J. Buffy coat pooled platelet concentrate: A new age platelet component. Asian J Transfus Sci. 2021 Jul-Dec;15(2):125-132. doi: 10.4103/ajts.AJTS_72_19. Epub 2021 Nov 1. PMID: 34908742; PMCID: PMC8628246.</ref> |
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==Storage== |
==Storage== |
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Whole blood is typically stored under the same conditions as red blood cells and can be kept up to 35 days if collected with CPDA-1 storage solution or 21 days with other common storage solutions such as CPD. |
Whole blood is typically stored under the same conditions as red blood cells and can be kept up to 35 days if collected with CPDA-1 storage solution or 21 days with other common storage solutions such as CPD.{{cn|date=December 2021}} |
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If the blood is used to make platelets, it is kept at room temperature until the process is complete. This must be done quickly to minimize the warm storage of RBCs in the unit. |
If the blood is used to make platelets, it is kept at room temperature until the process is complete. This must be done quickly to minimize the warm storage of RBCs in the unit.{{cn|date=December 2021}} |
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== References == |
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In the US, the capitalized "Whole Blood" means a specific standardized product for transfusion or further processing, where "whole blood" is any unmodified collected blood. |
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==References== |
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{{reflist|32em}} |
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==External links== |
== External links == |
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* [ |
* [https://www.fda.gov/vaccines-blood-biologics/blood-blood-products Blood & Blood Products] from U.S. [[Food and Drug Administration]] (FDA) |
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{{Transfusion medicine}} |
{{Transfusion medicine}} |
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{{Intravenous therapy}} |
{{Intravenous therapy}} |
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[[Category:Blood products]] |
[[Category:Blood products]] |
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[[Category:World Health Organization essential medicines]] |
[[Category:World Health Organization essential medicines]] |
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[[Category:Transfusion medicine]] |
[[Category:Transfusion medicine]] |
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[[Category:Wikipedia medicine articles ready to translate]] |
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Latest revision as of 07:29, 30 November 2024
 A Red Cross whole blood donation | |
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| Routes of administration | IV |
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Whole blood (WB) is human blood from a standard blood donation.[1] It is used in the treatment of massive bleeding, in exchange transfusion, and when people donate blood to themselves.[1][2] One unit of whole blood (approximately 450 mL) brings up hemoglobin levels by about 10 g/L.[3][4] Cross matching is typically done before the blood is given.[2][5] It is given by injection into a vein.[6]
Side effects include red blood cell breakdown, high blood potassium, infection, volume overload, lung injury, and allergic reactions such as anaphylaxis.[2][3] Whole blood is made up of red blood cells, white blood cells, platelets, and blood plasma.[3] It is best within a day of collection; however, can be used for up to three weeks.[3][5][7] The blood is typically combined with an anticoagulant and preservative during the collection process.[8]
The first transfusion of whole blood was in 1818; however, common use did not begin until the First and Second World Wars.[5][9] It is on the World Health Organization's List of Essential Medicines.[10] In the 1980s the cost of whole blood was about US$50 per unit in the United States.[11] Whole blood is not commonly used outside of the developing world and military.[2] It is used to make a number of blood products including packed red blood cells, platelet concentrate, cryoprecipitate, and fresh frozen plasma.[1]
Medical use
[edit]Whole blood has similar risks to a transfusion of red blood cells and must be cross-matched to avoid hemolytic transfusion reactions. Most of the reasons for use are the same as those for RBCs, and whole blood is not frequently used in high income countries where packed red blood cells are readily available.[12][13] However, use of whole blood is much more common in low and middle income countries. Over 40% of blood collected in low-income countries is administered as whole blood, and approximately a third of all blood collected in middle-income countries is administered as whole blood.[14]
Whole blood is sometimes "recreated" from stored red blood cells and fresh frozen plasma (FFP) for neonatal transfusions. This is done to provide a final product with a very specific hematocrit (percentage of red cells) with type O red cells and type AB plasma to minimize the chance of complications.[15]
Transfusion of whole blood is being used in the military setting and is being studied in pre-hospital trauma care and in the setting of massive transfusion in the civilian setting.[12][16][17][13] Whole blood can be ABO-type specific when the recipient blood type is known. For unknown recipient type, low-titer O universal donor whole blood (LTOWB) can be used; this requires that the donor plasma contains only low titers of anti-A and anti-B.[18]
Processing
[edit]Historically, blood was transfused as whole blood without further processing. Most blood banks now split the whole blood into two or more components,[19] typically red blood cells and a plasma component such as fresh frozen plasma. Platelets for transfusion can also be prepared from a unit of whole blood. Some blood banks have replaced this with platelets collected by plateletpheresis because whole blood platelets, sometimes called "random donor" platelets, must be pooled from multiple donors to get enough for an adult therapeutic dose.[20]
The collected blood is generally separated into components by one of three methods. A centrifuge can be used in a "hard spin" which separates whole blood into plasma and red cells or a "soft spin" which separates it into plasma, buffy coat (used to make platelets), and red blood cells. The third method is sedimentation: the blood simply sits overnight and the red cells and plasma are separated by gravitational interactions. Preparing a pooled buffy coat concentrate may provide additional advantages.[21]
Storage
[edit]Whole blood is typically stored under the same conditions as red blood cells and can be kept up to 35 days if collected with CPDA-1 storage solution or 21 days with other common storage solutions such as CPD.[citation needed]
If the blood is used to make platelets, it is kept at room temperature until the process is complete. This must be done quickly to minimize the warm storage of RBCs in the unit.[citation needed]
References
[edit]- ^ a b c Hess JR, Beyer GM (2007). "Red Blood Cell Metabolism During Storage: Basic Principles and Practical Aspects". In Hillyer CD (ed.). Blood Banking and Transfusion Medicine: Basic Principles & Practice. Elsevier Health Sciences. p. 190. ISBN 978-0443069819. Archived from the original on 2017-01-12.
- ^ a b c d Connell NT (December 2016). "Transfusion Medicine". Primary Care. 43 (4): 651–659. doi:10.1016/j.pop.2016.07.004. PMID 27866583.
- ^ a b c d Plumer AL (2007). "Transfusion Therapy". Plumer's Principles and Practice of Intravenous Therapy. Lippincott Williams & Wilkins. p. 422. ISBN 9780781759441. Archived from the original on 2017-01-12.
- ^ Woodson LC, Sherwood ER, Kinsky MP, Talon M, Martinello C, Woodson SM (2012). "Anesthesia for burned patients". In Herndon DN (ed.). Total Burn Care: Expert Consult - Online and Print. Elsevier Health Sciences. p. 194. ISBN 9781455737970.
- ^ a b c Bahr MP, Yazer MH, Triulzi DJ, Collins RA (December 2016). "Whole blood for the acutely haemorrhaging civilian trauma patient: a novel idea or rediscovery?". Transfusion Medicine. 26 (6): 406–414. doi:10.1111/tme.12329. PMID 27357229. S2CID 24552025.
- ^ Flagg C (2015). "Intravenous Therapy". In Linton AD (ed.). Introduction to Medical-Surgical Nursing. Elsevier Health Sciences. p. 287. ISBN 9781455776412. Archived from the original on 2017-09-14.
- ^ Marini JF, Wheeler AP (2012). "Blood Conservation and Transfusion". Critical Care Medicine: The Essentials (4th ed.). Lippincott Williams & Wilkins. p. 267. ISBN 9781451152845. Archived from the original on 2017-01-11.
- ^ Rudmann SV, ed. (2005). "Donor Screening and Blood Collection". Textbook of Blood Banking and Transfusion Medicine. Elsevier Health Sciences. p. 205. ISBN 072160384X. Archived from the original on 2017-01-12.
- ^ Tanaka K (2012). "Transfusion and Coagulation Therapy". In Hemmings HC, Egan TD (eds.). Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application. Elsevier Health Sciences. p. 628. ISBN 978-1455737932. Archived from the original on 2017-01-11.
- ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
- ^ "Introduction and Summary". Blood policy & technology. DIANE Publishing. 1985. p. 8. ISBN 9781428923331. Archived from the original on 2017-01-12.
- ^ a b Flint AW, McQuilten ZK, Wood EM (April 2018). "Massive transfusions for critical bleeding: is everything old new again?". Transfusion Medicine. 28 (2): 140–149. doi:10.1111/tme.12524. PMID 29607593. S2CID 4561424.
- ^ a b Pivalizza EG, Stephens CT, Sridhar S, Gumbert SD, Rossmann S, Bertholf MF, et al. (July 2018). "Whole Blood for Resuscitation in Adult Civilian Trauma in 2017: A Narrative Review". Anesthesia and Analgesia. 127 (1): 157–162. doi:10.1213/ANE.0000000000003427. PMID 29771715. S2CID 21697290.
- ^ "Blood safety and availability". www.who.int. Retrieved 2019-06-22.
- ^ Sharma DC, Rai S, Mehra A, Kaur MM, Sao S, Gaur A, Sapra R. Study of 25 cases of exchange transfusion by reconstituted blood in hemolytic disease of newborn. Asian J Transfus Sci. 2007 Jul;1(2):56-8. doi: 10.4103/0973-6247.33448. PMID: 21938234; PMCID: PMC3168121.
- ^ "Blood Far Forward". THOR. Retrieved 2019-06-22.
- ^ Goforth CW, Tranberg JW, Boyer P, Silvestri PJ (June 2016). "Fresh Whole Blood Transfusion: Military and Civilian Implications". Critical Care Nurse. 36 (3): 50–57. doi:10.4037/ccn2016780. PMID 27252101.
- ^ Milford EM, Gurney JM, Beckett A, Strandenes G, Reade MC. Type-specific whole blood still has a role in the era of low titer O universal donor transfusion for severe trauma hemorrhage. J Trauma Acute Care Surg. 2024 May 20. doi: 10.1097/TA.0000000000004369. Epub ahead of print. PMID: 38764142.
- ^ Greene CE, Hillyer CD (17 June 2009). "Component preparation and manufacturing". In Hillyer CD, Shaz BH, Zimring JC, Abshire TC (eds.). Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects. Elsevier. pp. 45–. ISBN 978-0-12-374432-6. Archived from the original on 23 September 2017. Retrieved 16 November 2010.
- ^ Chu YH, Rose WN, Nawrot W, Raife TJ. Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology. J Int Med Res. 2021 May;49(5):3000605211016748. doi: 10.1177/03000605211016748. PMID: 34013757; PMCID: PMC8142527.
- ^ Kumar R, Dhawan HK, Sharma RR, Kaur J. Buffy coat pooled platelet concentrate: A new age platelet component. Asian J Transfus Sci. 2021 Jul-Dec;15(2):125-132. doi: 10.4103/ajts.AJTS_72_19. Epub 2021 Nov 1. PMID: 34908742; PMCID: PMC8628246.
External links
[edit]- Blood & Blood Products from U.S. Food and Drug Administration (FDA)
