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{{Short description|Increased blood pH}} |
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{{More citations needed|date=March 2015}} |
{{More citations needed|date=March 2015}} |
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{{Infobox medical condition (new) |
{{Infobox medical condition (new) |
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| name = Alkalosis |
| name = Alkalosis |
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==Causes== |
==Causes== |
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Respiratory alkalosis is caused by [[hyperventilation]],<ref name="Yee2010">{{ |
Respiratory alkalosis is caused by [[hyperventilation]],<ref name="Yee2010">{{Cite journal |vauthors=Yee AH, Rabinstein AA |date=February 2010 |title=Neurologic presentations of acid-base imbalance, electrolyte abnormalities, and endocrine emergencies |journal=Neurol Clin |volume=28 |issue=1 |pages=1–16 |doi=10.1016/j.ncl.2009.09.002 |pmid=19932372}}</ref> resulting in a loss of [[carbon dioxide]]. Compensatory mechanisms for this include release of hydrogen ion from tissue buffers and excretion of [[bicarbonate]] in the kidneys, both of which lower blood [[pH]].<ref name="Harrisons">{{Cite book |last=Norman G. Levinsky |title=Harrison's Principles of Internal Medicine |date=1987 |publisher=McGraw-Hill |isbn=0-07-100134-4 |editor-last=[[Eugene Braunwald]] |edition=11 |pages=212–214 |display-editors=etal}}</ref> Hyperventilation-induced alkalosis can be seen in several deadly [[central nervous system]] diseases such as [[stroke]]s or [[Rett syndrome]].<ref name="Yee2010" /> |
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In [[Glycogen storage disease type V|McArdle disease]] (glycogen storage disease type V), the inability to utilize muscle glycogen leads to a shortage of ATP during exercise and subsequent exercise-induced premature [[muscle fatigue]], muscle cramps, muscle pain (myalgia), inappropriate rapid heart rate response to exercise ([[tachycardia]]), rapid depletion of phosphocreatine, insufficient ATP production, increased ADP and AMP, increased rise in venous ammonia (from the [[purine nucleotide cycle]]), increased epinephrine (adrenaline), increased plasma free fatty acids (lipolysis), increased venous pH (alkalosis), rapid ([[tachypnea]]) and commonly (approx. 50%) also heavy breathing ([[hyperpnea]]), that is exercise hyperventilation.<ref>{{Cite journal | |
In [[Glycogen storage disease type V|McArdle disease]] (glycogen storage disease type V), the inability to utilize muscle glycogen leads to a shortage of ATP during exercise and subsequent exercise-induced premature [[muscle fatigue]], muscle cramps, muscle pain (myalgia), inappropriate rapid heart rate response to exercise ([[tachycardia]]), rapid depletion of phosphocreatine, insufficient ATP production, increased ADP and AMP, increased rise in venous ammonia (from the [[purine nucleotide cycle]]), increased epinephrine (adrenaline), increased plasma free fatty acids (lipolysis), increased venous pH (alkalosis), rapid ([[tachypnea]]) and commonly (approx. 50%) also heavy breathing ([[hyperpnea]]), that is exercise hyperventilation.<ref>{{Cite journal |last=Zange |first=Jochen |last2=Grehl |first2=Torsten |last3=Disselhorst-Klug |first3=Catherine |last4=Rau |first4=Günter |last5=Müller |first5=Klaus |last6=Schröder |first6=Rolf |last7=Tegenthoff |first7=Martin |last8=Malin |first8=Jean-Pierre |last9=Vorgerd |first9=Matthias |date=June 2003 |title=Breakdown of adenine nucleotide pool in fatiguing skeletal muscle in McArdle's disease: a noninvasive 31P-MRS and EMG study |url=https://pubmed.ncbi.nlm.nih.gov/12766985/ |journal=Muscle & Nerve |volume=27 |issue=6 |pages=728–736 |doi=10.1002/mus.10377 |issn=0148-639X |pmid=12766985}}</ref><ref>{{Cite journal |last=Kitaoka |first=Yu |date=2014-02-25 |title=McArdle Disease and Exercise Physiology |journal=Biology |volume=3 |issue=1 |pages=157–166 |doi=10.3390/biology3010157 |issn=2079-7737 |pmc=4009758 |pmid=24833339 |doi-access=free}}</ref><ref name=":0">{{Cite journal |last=Rodriguez-Lopez |first=Carlos |last2=Santalla |first2=Alfredo |last3=Valenzuela |first3=Pedro L. |last4=Real-Martínez |first4=Alberto |last5=Villarreal-Salazar |first5=Mónica |last6=Rodriguez-Gomez |first6=Irene |last7=Pinós |first7=Tomàs |last8=Ara |first8=Ignacio |last9=Lucia |first9=Alejandro |date=February 2023 |title=Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease |journal=The Journal of Physiology |volume=601 |issue=3 |pages=551–566 |doi=10.1113/JP283743 |issn=1469-7793 |pmc=10099855 |pmid=36370371}}</ref><ref name=":1">{{Cite journal |last=Ørngreen |first=Mette Cathrine |last2=Jeppesen |first2=Tina Dysgaard |last3=Taivassalo |first3=Tanja |last4=Hauerslev |first4=Simon |last5=Preisler |first5=Nicolai |last6=Heinicke |first6=Katja |last7=Haller |first7=Ronald G. |last8=Vissing |first8=John |last9=van Hall |first9=Gerrit |date=August 2015 |title=Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease) |url=https://pubmed.ncbi.nlm.nih.gov/26030324/ |journal=The Journal of Clinical Endocrinology and Metabolism |volume=100 |issue=8 |pages=E1096–1104 |doi=10.1210/jc.2015-1339 |issn=1945-7197 |pmid=26030324}}</ref><ref name=":2">{{Cite journal |last=Hagberg |first=J. M. |last2=Coyle |first2=E. F. |last3=Carroll |first3=J. E. |last4=Miller |first4=J. M. |last5=Martin |first5=W. H. |last6=Brooke |first6=M. H. |date=April 1982 |title=Exercise hyperventilation in patients with McArdle's disease |url=https://pubmed.ncbi.nlm.nih.gov/6953061/ |journal=Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology |volume=52 |issue=4 |pages=991–994 |doi=10.1152/jappl.1982.52.4.991 |issn=0161-7567 |pmid=6953061}}</ref><ref>{{Cite journal |last=Hagberg |first=J. M. |last2=King |first2=D. S. |last3=Rogers |first3=M. A. |last4=Montain |first4=S. J. |last5=Jilka |first5=S. M. |last6=Kohrt |first6=W. M. |last7=Heller |first7=S. L. |date=April 1990 |title=Exercise and recovery ventilatory and VO2 responses of patients with McArdle's disease |url=https://pubmed.ncbi.nlm.nih.gov/2347781/ |journal=Journal of Applied Physiology |volume=68 |issue=4 |pages=1393–1398 |doi=10.1152/jappl.1990.68.4.1393 |issn=8750-7587 |pmid=2347781}}</ref> During exercise, due to the inability to utilize muscle glycogen as a substrate for ATP synthesis, plasma lactate does not significantly rise (and may fall below) compared to resting levels; consequently, McArdle disease individuals do not experience lactic acidosis.<ref name=":1" /> The rise in venous pH (alkalosis), may be due to increased ammonia production,<ref>{{Cite web |title=Metabolic disease in neonates: Initial metabolic tests for suspected metabolic disease |url=https://www.safercare.vic.gov.au/best-practice-improvement/clinical-guidance/neonatal/metabolic-disease-in-neonates |website=Safer Care Victoria}}</ref> increased epinephrine, and/or increased oxygen demand for oxidative phosphorylation of blood borne substrates (free fatty acids and blood glucose).<ref name=":2" /><ref name=":0" /> |
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Metabolic alkalosis can be caused by repeated vomiting,<ref name="Yee2010"/> resulting in a loss of [[hydrochloric acid]] in the stomach contents. Severe [[dehydration]], and the consumption of [[alkali]],<ref name=Harrisons/> are other causes. It can also be caused by administration of diuretics<ref name="Yee2010"/> and endocrine disorders such as [[Cushing's syndrome]]. Compensatory mechanism for metabolic alkalosis involve slowed breathing by the lungs to increase [[Serum (blood)|serum]] carbon dioxide,<ref name="Yee2010"/> a condition leaning toward respiratory [[acidosis]]. As respiratory acidosis often accompanies the compensation for metabolic alkalosis, and vice versa, a delicate balance is created between these two conditions. |
Metabolic alkalosis can be caused by repeated vomiting,<ref name="Yee2010" /> resulting in a loss of [[hydrochloric acid]] in the stomach contents. Severe [[dehydration]], and the consumption of [[alkali]],<ref name=Harrisons/> are other causes. It can also be caused by administration of diuretics<ref name="Yee2010" /> and endocrine disorders such as [[Cushing's syndrome]]. Compensatory mechanism for metabolic alkalosis involve slowed breathing by the lungs to increase [[Serum (blood)|serum]] carbon dioxide,<ref name="Yee2010" /> a condition leaning toward respiratory [[acidosis]]. As respiratory acidosis often accompanies the compensation for metabolic alkalosis, and vice versa, a delicate balance is created between these two conditions. |
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==See also== |
==See also== |
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== External links == |
== External links == |
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{{Medical resources |
{{Medical resources |
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| DiseasesDB = 32458 |
| DiseasesDB = 32458 |
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| ICD10 = {{ICD10|E|87|3|e|70}} |
| ICD10 = {{ICD10|E|87|3|e|70}} |
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| ICD9 = {{ICD9|276.3}} |
| ICD9 = {{ICD9|276.3}} |
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| ICDO = |
| ICDO = |
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| OMIM = |
| OMIM = |
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| MedlinePlus = 001183 |
| MedlinePlus = 001183 |
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| eMedicineSubj = |
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| eMedicineTopic = |
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| MeshID = D000471 |
| MeshID = D000471 |
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*{{GoldBookRef|title=alkalosis|file=A00221}} |
* {{GoldBookRef|title=alkalosis|file=A00221}} |
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{{Fluid, electrolyte, acid base metabolic pathology}} |
{{Fluid, electrolyte, acid base metabolic pathology}} |
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Latest revision as of 14:32, 20 November 2024
 | This article needs additional citations for verification. (March 2015) |
| Alkalosis | |
|---|---|
| Specialty | Endocrinology  |
Alkalosis is the result of a process reducing hydrogen ion concentration of arterial blood plasma (alkalemia). In contrast to acidemia (serum pH 7.35 or lower), alkalemia occurs when the serum pH is higher than normal (7.45 or higher). Alkalosis is usually divided into the categories of respiratory alkalosis and metabolic alkalosis or a combined respiratory/metabolic alkalosis.[1]
Signs and symptoms
[edit]Metabolic alkalosis is usually accompanied by low blood potassium concentration, causing, e.g., muscular weakness, muscle pain, and muscle cramps (from disturbed function of the skeletal muscles), and muscle spasms (from disturbed function of smooth muscles).
It may also cause low blood calcium concentration. As the blood pH increases, blood transport proteins, such as albumin, become more ionized into anions. This causes the free calcium present in blood to bind more strongly with albumin. If severe, it may cause tetany.
Causes
[edit]Respiratory alkalosis is caused by hyperventilation,[2] resulting in a loss of carbon dioxide. Compensatory mechanisms for this include release of hydrogen ion from tissue buffers and excretion of bicarbonate in the kidneys, both of which lower blood pH.[3] Hyperventilation-induced alkalosis can be seen in several deadly central nervous system diseases such as strokes or Rett syndrome.[2]
In McArdle disease (glycogen storage disease type V), the inability to utilize muscle glycogen leads to a shortage of ATP during exercise and subsequent exercise-induced premature muscle fatigue, muscle cramps, muscle pain (myalgia), inappropriate rapid heart rate response to exercise (tachycardia), rapid depletion of phosphocreatine, insufficient ATP production, increased ADP and AMP, increased rise in venous ammonia (from the purine nucleotide cycle), increased epinephrine (adrenaline), increased plasma free fatty acids (lipolysis), increased venous pH (alkalosis), rapid (tachypnea) and commonly (approx. 50%) also heavy breathing (hyperpnea), that is exercise hyperventilation.[4][5][6][7][8][9] During exercise, due to the inability to utilize muscle glycogen as a substrate for ATP synthesis, plasma lactate does not significantly rise (and may fall below) compared to resting levels; consequently, McArdle disease individuals do not experience lactic acidosis.[7] The rise in venous pH (alkalosis), may be due to increased ammonia production,[10] increased epinephrine, and/or increased oxygen demand for oxidative phosphorylation of blood borne substrates (free fatty acids and blood glucose).[8][6]
Metabolic alkalosis can be caused by repeated vomiting,[2] resulting in a loss of hydrochloric acid in the stomach contents. Severe dehydration, and the consumption of alkali,[3] are other causes. It can also be caused by administration of diuretics[2] and endocrine disorders such as Cushing's syndrome. Compensatory mechanism for metabolic alkalosis involve slowed breathing by the lungs to increase serum carbon dioxide,[2] a condition leaning toward respiratory acidosis. As respiratory acidosis often accompanies the compensation for metabolic alkalosis, and vice versa, a delicate balance is created between these two conditions.
See also
[edit]References
[edit]- ^ Mosby's Paramedic Textbook – Mick J. Sanders
- ^ a b c d e Yee AH, Rabinstein AA (February 2010). "Neurologic presentations of acid-base imbalance, electrolyte abnormalities, and endocrine emergencies". Neurol Clin. 28 (1): 1–16. doi:10.1016/j.ncl.2009.09.002. PMID 19932372.
- ^ a b Norman G. Levinsky (1987). Eugene Braunwald; et al. (eds.). Harrison's Principles of Internal Medicine (11 ed.). McGraw-Hill. pp. 212–214. ISBN 0-07-100134-4.
- ^ Zange, Jochen; Grehl, Torsten; Disselhorst-Klug, Catherine; Rau, Günter; Müller, Klaus; Schröder, Rolf; Tegenthoff, Martin; Malin, Jean-Pierre; Vorgerd, Matthias (June 2003). "Breakdown of adenine nucleotide pool in fatiguing skeletal muscle in McArdle's disease: a noninvasive 31P-MRS and EMG study". Muscle & Nerve. 27 (6): 728–736. doi:10.1002/mus.10377. ISSN 0148-639X. PMID 12766985.
- ^ Kitaoka, Yu (2014-02-25). "McArdle Disease and Exercise Physiology". Biology. 3 (1): 157–166. doi:10.3390/biology3010157. ISSN 2079-7737. PMC 4009758. PMID 24833339.
- ^ a b Rodriguez-Lopez, Carlos; Santalla, Alfredo; Valenzuela, Pedro L.; Real-Martínez, Alberto; Villarreal-Salazar, Mónica; Rodriguez-Gomez, Irene; Pinós, Tomàs; Ara, Ignacio; Lucia, Alejandro (February 2023). "Muscle glycogen unavailability and fat oxidation rate during exercise: Insights from McArdle disease". The Journal of Physiology. 601 (3): 551–566. doi:10.1113/JP283743. ISSN 1469-7793. PMC 10099855. PMID 36370371.
- ^ a b Ørngreen, Mette Cathrine; Jeppesen, Tina Dysgaard; Taivassalo, Tanja; Hauerslev, Simon; Preisler, Nicolai; Heinicke, Katja; Haller, Ronald G.; Vissing, John; van Hall, Gerrit (August 2015). "Lactate and Energy Metabolism During Exercise in Patients With Blocked Glycogenolysis (McArdle Disease)". The Journal of Clinical Endocrinology and Metabolism. 100 (8): E1096–1104. doi:10.1210/jc.2015-1339. ISSN 1945-7197. PMID 26030324.
- ^ a b Hagberg, J. M.; Coyle, E. F.; Carroll, J. E.; Miller, J. M.; Martin, W. H.; Brooke, M. H. (April 1982). "Exercise hyperventilation in patients with McArdle's disease". Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 52 (4): 991–994. doi:10.1152/jappl.1982.52.4.991. ISSN 0161-7567. PMID 6953061.
- ^ Hagberg, J. M.; King, D. S.; Rogers, M. A.; Montain, S. J.; Jilka, S. M.; Kohrt, W. M.; Heller, S. L. (April 1990). "Exercise and recovery ventilatory and VO2 responses of patients with McArdle's disease". Journal of Applied Physiology. 68 (4): 1393–1398. doi:10.1152/jappl.1990.68.4.1393. ISSN 8750-7587. PMID 2347781.
- ^ "Metabolic disease in neonates: Initial metabolic tests for suspected metabolic disease". Safer Care Victoria.
External links
[edit]- IUPAC, Compendium of Chemical Terminology, 2nd ed. (the "Gold Book") (1997). Online corrected version: (2006–) "alkalosis". doi:10.1351/goldbook.A00221
