Talk:Receptor theory: Difference between revisions

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Pharmacology Mid‑importance

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Molecular Biology: MCB / Cell Signaling

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Created page

Created page on receptor theory think it will make a nice addition to wikipedia will be writing it over the coming weeks Lilypink 21:00, 1 November 2007 (UTC) please feel free to make comments on this topic here[reply]

Re: Definition of receptor theory this is what i think it is so far from what I read on the topic but if you think you have a better one change it. Lilypink 20:18, 2 November 2007 (UTC)[reply]

Re: Ternary complex model - There is an acronym (ATCM) floating around with no definition earlier in the article - may be worth a clear up AbiF95 (talk) 12:00, 28 April 2016 (UTC)[reply]

I fear that some of the history in this article is wrong. And it refers mostly to GPCR, in which it is still impossible to fit models and estimate their parameters. It should refer also to ligand-gated ion channels because they are still the only system in which it is possible to fit mechanisms to observations and to estimate all the free parameters (transition rate constants). That makes it possible to compare postulated mechanisms in a proper quantitative way. David Colquhoun (talk) 15:12, 10 July 2023 (UTC)[reply]

New section on Receptor Theory in Immunology

CPDeLisi has added a new section called Receptor theory in Immunology. I dispute that the material should be included, because it does not appear relevant to the current article. Specifically, the article's topic appears to be about a hypothesis held during the early 20th century regarding pharmacology, and the mechanisms of drug / cell interaction. The term "receptor theory" appears very much to refer to the hypothesis that existed prior to the actual understanding of the bioichemical processes involved. On the other hand, the new section appears to concern itself with advances in the biochemistry that occurred in the 1960s and 1970s, after the "Receptor theory" had been validated and the since had moved on to simply study receptors. I invite CPDeLisi (or any other interested editor) to discuss the matter to decide whether the new material should be retained and improved, or simply removed as not relevant to the present topic. WikiDan61^ChatMe!_ReadMe!! 20:51, 23 July 2020 (UTC)[reply]

@CPDeLisi: No response? WikiDan61^ChatMe!_ReadMe!! 11:44, 28 July 2020 (UTC)[reply]

Apparently CPDeLisi does not choose to defend his addition, so I will again remove it. WikiDan61^ChatMe!_ReadMe!! 17:41, 29 July 2020 (UTC)[reply]

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 Re: Ternary complex model - There is an acronym (ATCM) floating around with no definition earlier in the article - may be worth a clear up [[User:AbiF95|AbiF95]] ([[User talk:AbiF95|talk]]) 12:00, 28 April 2016 (UTC)
+I fear that some of the history in this article is wrong.  And it refers mostly to GPCR, in which it is still impossible to fit models and estimate their parameters.  It should refer also to ligand-gated ion channels because they are still the only system in which it is possible to fit mechanisms to observations and to estimate all the free parameters (transition rate constants). That makes it possible to compare postulated mechanisms in a proper quantitative way.
+[[User:David Colquhoun|David Colquhoun]] ([[User talk:David Colquhoun|talk]]) 15:12, 10 July 2023 (UTC)
 == New section on Receptor Theory in Immunology ==