Jump to content

Interleukin-7 receptor: Difference between revisions

Add links
From Wikipedia, the free encyclopedia
Browse history interactively
← Previous edit
Content deleted Content added
VisualWikitext
Removing Immunology supercategory (already member of a subcategory)
OAbot (talk | contribs)
Bots
438,441 edits
m Open access bot: doi updated in citation with #oabot.
 
(17 intermediate revisions by 12 users not shown)
Line 1: Line 1:
{{Short description|Protein found on the surface of cells}}
[[File:IL-7receptor and signaling.jpg|thumb|300px|right|'''IL-7 receptor and signaling''', common γ chain (blue) and IL-7 receptor-α (green)]]
[[File:IL-7receptor and signaling.jpg|thumb|300px|right|'''IL-7 receptor and signaling''', common γ chain (blue) and IL-7 receptor-α (green)]]


{{protein
{{infobox protein
| Name = [[Interleukin-7 receptor-α]]
| Name = [[Interleukin-7 receptor-α]]
| caption =
| caption =
Line 20: Line 21:
| LocusSupplementaryData =
| LocusSupplementaryData =
}}
}}
{{protein
{{infobox protein
|Name= [[IL2RG|interleukin 2 receptor, gamma]]
|Name= [[IL2RG|interleukin 2 receptor, gamma]]
|caption=
|caption=
| image = Protein_IL2RG_PDB_2b5i.png
| image = Protein_IL2RG_PDB_2b5i.png
| image_source = Crystallographic structure of [[Interleukin 2|IL-2]] (center [[alpha helix|alpha helices]]) complexed with the common gamma chain (IL2RG; 10 O'Clock to 1 O'Clock), [[IL2RA]] (4 O'Clock), and [[IL2RB]] (7 O'Clock to 9 O'Clock). Each protein is individually rainbow colored ([[N-terminus]] = blue, [[C-terminus]] = red).<ref name="pmid16293754">{{PDB|2B5I}}{{cite journal | author = Wang X, Rickert M, Garcia KC | title = Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors | journal = Science | volume = 310 | issue = 5751 | pages = 1159–63 |date=November 2005 | pmid = 16293754 | doi = 10.1126/science.1117893 | url = }}</ref>
| image_source = Crystallographic structure of [[Interleukin 2|IL-2]] (center [[alpha helix|alpha helices]]) complexed with the common gamma chain (IL2RG; 10 O'Clock to 1 O'Clock), [[IL2RA]] (4 O'Clock), and [[IL2RB]] (7 O'Clock to 9 O'Clock). Each protein is individually rainbow colored ([[N-terminus]] = blue, [[C-terminus]] = red).<ref name="pmid16293754">{{PDB|2B5I}}{{cite journal |vauthors=Wang X, Rickert M, Garcia KC | title = Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors | journal = Science | volume = 310 | issue = 5751 | pages = 1159–63 |date=November 2005 | pmid = 16293754 | doi = 10.1126/science.1117893 | bibcode = 2005Sci...310.1159W | s2cid = 85394260 }}</ref>
|width=
|width=
| HGNCid=6010
| HGNCid=6010
Line 41: Line 42:
}}
}}


The '''[[Interleukin_7|interleukin-7]] receptor''' is a [[protein]] found on the surface of [[Cell (biology)|cells]]. It is made up of two different smaller protein chains - i.e. it is a [[heterodimer]], and consists of two subunits, interleukin-7 receptor-α ([[CD127]]) and common-γ chain receptor ([[CD132]]).<ref name="pmid8266077">{{cite journal | author = Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ | title = Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor | journal = Science | volume = 262 | issue = 5141 | pages = 1877–80 |date=December 1993 | pmid = 8266077 | doi = 10.1126/science.8266077 }}</ref><ref name="pmid9010926">{{cite journal | author = Kroemer RT, Richards WG | title = Homology modeling study of the human interleukin-7 receptor complex | journal = Protein Eng. | volume = 9 | issue = 12 | pages = 1135–42 |date=December 1996 | pmid = 9010926 | doi = 10.1093/protein/9.12.1135 }}</ref> The common-γ chain receptors is shared with various cytokines, including interleukin[[Interleukin-2|-2]], [[Interleukin-4|-4]], [[Interleukin-9|-9]], and [[Interleukin-15|-15]]. Interleukin-7 receptor is expressed on various cell types, including [[naive T cells|naive]] and [[memory T cells]] and many others.
The '''[[Interleukin 7|interleukin-7]] receptor''' is a [[protein]] found on the surface of [[Cell (biology)|cells]]. It is made up of two different smaller protein chains - i.e. it is a [[heterodimer]], and consists of two subunits, interleukin-7 receptor-α ([[CD127]]) and common-γ chain receptor ([[CD132]]).<ref name="pmid8266077">{{cite journal |vauthors=Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ | title = Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor | journal = Science | volume = 262 | issue = 5141 | pages = 1877–80 |date=December 1993 | pmid = 8266077 | doi = 10.1126/science.8266077 | bibcode = 1993Sci...262.1877N | url = https://zenodo.org/record/1231251 }}</ref><ref name="pmid9010926">{{cite journal |vauthors=Kroemer RT, Richards WG | title = Homology modeling study of the human interleukin-7 receptor complex | journal = Protein Eng. | volume = 9 | issue = 12 | pages = 1135–42 |date=December 1996 | pmid = 9010926 | doi = 10.1093/protein/9.12.1135 | doi-access = }}</ref> The common-γ chain receptors is shared with various cytokines, including [[interleukin-2]], [[Interleukin-4|-4]], [[Interleukin-9|-9]], and [[Interleukin-15|-15]].<ref>{{cite web |url= http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=305#2300|title= IL2 family |website= Guide to Pharmacology|publisher= IUPHAR/BPS|access-date= 21 August 2015}}</ref> Interleukin-7 receptor is expressed on various cell types, including [[naive T cells|naive]] and [[memory T cells]] and many others.


== Function ==
== Function ==


Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as [[V(D)J recombination]]{{Citation needed|date=September 2011}}. This protein is also found to control the accessibility of a region of the [[genome]] that contains the [[T-cell receptor]] gamma gene, by [[STAT5]] and histone acetylation {{Citation needed|date=September 2011}}. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).<ref name="entrez">{{cite web | title = Entrez Gene: IL7R interleukin 7 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575| accessdate = }}</ref>
Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as [[V(D)J recombination]]{{Citation needed|date=September 2011}}. This protein is also found to control the accessibility of a region of the [[genome]] that contains the [[T-cell receptor]] gamma gene, by [[STAT5]] and histone acetylation {{Citation needed|date=September 2011}}. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).<ref name="entrez">{{cite web | title = Entrez Gene: IL7R interleukin 7 receptor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575}}</ref>


== Diseases ==
== Diseases ==


Several diseases are associated with Interleukin-7 receptor including [[T-cell acute lymphoblastic leukemia|T-cell acute lymphoblastic leukaemia]],<ref name="pmid21892159">{{cite journal | author = Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT | title = Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia | journal = Nat. Genet. | volume = 43 | issue = 10 | pages = 932–9 |date=October 2011 | pmid = 21892159 | doi = 10.1038/ng.924 }}</ref> [[multiple sclerosis]],<ref name="pmid17660817">{{cite journal | author = Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL | title = Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis | journal = Nat. Genet. | volume = 39 | issue = 9 | pages = 1083–91 |date=September 2007 | pmid = 17660817 | doi = 10.1038/ng2103 }}</ref> [[rheumatoid arthritis]] and [[juvenile idiopathic arthritis]].<ref name="pmid19744146">{{cite journal | author = O'Doherty C, Alloza I, Rooney M, Vandenbroeck K | title = IL7RA polymorphisms and chronic inflammatory arthropathies | journal = Tissue Antigens | volume = 74 | issue = 5 | pages = 429–31 |date=November 2009 | pmid = 19744146 | doi = 10.1111/j.1399-0039.2009.01342.x }}</ref>
Several diseases are associated with Interleukin-7 receptor including [[T-lymphoblastic leukemia/lymphoma|T-cell acute lymphoblastic leukaemia]],<ref name="pmid21892159">{{cite journal |vauthors=Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT | title = Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia | journal = Nat. Genet. | volume = 43 | issue = 10 | pages = 932–9 |date=October 2011 | pmid = 21892159 | doi = 10.1038/ng.924 | pmc = 7424552 }}</ref> [[multiple sclerosis]],<ref name="pmid17660817">{{cite journal |vauthors=Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL | title = Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis | journal = Nat. Genet. | volume = 39 | issue = 9 | pages = 1083–91 |date=September 2007 | pmid = 17660817 | doi = 10.1038/ng2103 | s2cid = 16426835 }}</ref> [[rheumatoid arthritis]] and [[juvenile idiopathic arthritis]].<ref name="pmid19744146">{{cite journal |vauthors=O'Doherty C, Alloza I, Rooney M, Vandenbroeck K | title = IL7RA polymorphisms and chronic inflammatory arthropathies | journal = Tissue Antigens | volume = 74 | issue = 5 | pages = 429–31 |date=November 2009 | pmid = 19744146 | doi = 10.1111/j.1399-0039.2009.01342.x }}</ref>


==See also==
==See also==
Line 62: Line 63:
{{NLM content}}
{{NLM content}}
{{Cytokine receptors|state=collapsed}}
{{Cytokine receptors|state=collapsed}}
{{Interleukin receptor modulators}}
{{Clusters of differentiation by lineage}}


[[Category:Type I cytokine receptors]]
[[Category:Type I cytokine receptors]]

{{transmembranereceptor-stub}}

Latest revision as of 00:43, 19 August 2023

IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green)
Interleukin-7 receptor-α
Identifiers
SymbolIL7R
Alt. symbolsCD127
NCBI gene3575
HGNC6024
OMIM146661
RefSeqNM_002185
UniProtP16871
Other data
LocusChr. 5 p13
Search for
StructuresSwiss-model
DomainsInterPro
interleukin 2 receptor, gamma
Identifiers
SymbolIL2RG
Alt. symbolsSCIDX1, IMD4, CD132
NCBI gene3561
HGNC6010
OMIM308380
RefSeqNM_000206
UniProtP31785
Other data
LocusChr. X q13
Search for
StructuresSwiss-model
DomainsInterPro

The interleukin-7 receptor is a protein found on the surface of cells. It is made up of two different smaller protein chains - i.e. it is a heterodimer, and consists of two subunits, interleukin-7 receptor-α (CD127) and common-γ chain receptor (CD132).[2][3] The common-γ chain receptors is shared with various cytokines, including interleukin-2, -4, -9, and -15.[4] Interleukin-7 receptor is expressed on various cell types, including naive and memory T cells and many others.

Function

[edit]

Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination[citation needed]. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation [citation needed]. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).[5]

Diseases

[edit]

Several diseases are associated with Interleukin-7 receptor including T-cell acute lymphoblastic leukaemia,[6] multiple sclerosis,[7] rheumatoid arthritis and juvenile idiopathic arthritis.[8]

See also

[edit]

References

[edit]
  1. ^ PDB: 2B5I​Wang X, Rickert M, Garcia KC (November 2005). "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors". Science. 310 (5751): 1159–63. Bibcode:2005Sci...310.1159W. doi:10.1126/science.1117893. PMID 16293754. S2CID 85394260.
  2. ^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. Bibcode:1993Sci...262.1877N. doi:10.1126/science.8266077. PMID 8266077.
  3. ^ Kroemer RT, Richards WG (December 1996). "Homology modeling study of the human interleukin-7 receptor complex". Protein Eng. 9 (12): 1135–42. doi:10.1093/protein/9.12.1135. PMID 9010926.
  4. ^ "IL2 family". Guide to Pharmacology. IUPHAR/BPS. Retrieved 21 August 2015.
  5. ^ "Entrez Gene: IL7R interleukin 7 receptor".
  6. ^ Zenatti PP, Ribeiro D, Li W, Zuurbier L, Silva MC, Paganin M, Tritapoe J, Hixon JA, Silveira AB, Cardoso BA, Sarmento LM, Correia N, Toribio ML, Kobarg J, Horstmann M, Pieters R, Brandalise SR, Ferrando AA, Meijerink JP, Durum SK, Yunes JA, Barata JT (October 2011). "Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia". Nat. Genet. 43 (10): 932–9. doi:10.1038/ng.924. PMC 7424552. PMID 21892159.
  7. ^ Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A, Caillier SJ, Ban M, Goris A, Barcellos LF, Lincoln R, McCauley JL, Sawcer SJ, Compston DA, Dubois B, Hauser SL, Garcia-Blanco MA, Pericak-Vance MA, Haines JL (September 2007). "Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis". Nat. Genet. 39 (9): 1083–91. doi:10.1038/ng2103. PMID 17660817. S2CID 16426835.
  8. ^ O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (November 2009). "IL7RA polymorphisms and chronic inflammatory arthropathies". Tissue Antigens. 74 (5): 429–31. doi:10.1111/j.1399-0039.2009.01342.x. PMID 19744146.
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Interleukin-7_receptor&oldid=1171092841"