View source for Histone 3′ UTR stem-loop

{{Infobox rfam
| Name = Histone 3′ UTR stem-loop
| image = RF00032.jpg
| width = 
| caption = Predicted [[secondary structure]] and [[sequence conservation]] of Histone3
| Symbol = Histone3
| AltSymbols = 
| Rfam = RF00032
| miRBase = 
| miRBase_family = 
| RNA_type = [[Cis-regulatory element|Cis-reg]]
| Tax_domain = [[Eukaryota]]
| GO = {{GO|0006398}} 
| SO = {{SO|0000205}} 
| CAS_number = 
| EntrezGene = 
| HGNCid = 
| OMIM = 
| PDB = 
| RefSeq = 
| Chromosome = 
| Arm = 
| Band = 
| LocusSupplementaryData = 
}}

The '''histone 3′ UTR stem-loop''' is an [[cis-regulatory element|RNA element]] involved in nucleocytoplasmic transport of the [[histone]] mRNAs, and in the regulation of stability and of translation efficiency in the [[cytoplasm]].  The [[mRNA]]s of [[metazoan]] [[histone]] genes lack [[polyadenylation]] and a [[poly-A tail]], instead 3′ end processing occurs at a site between this highly conserved stem-loop and a [[purine]] rich region around 20 [[nucleotide]]s downstream (the histone downstream element, or HDE).  The [[stem-loop]] is bound by a 31 kDa stem-loop binding protein ([[SLBP]] - also termed the histone hairpin binding protein, or HBP).  Together with [[U7 small nuclear RNA|U7 snRNA]] binding of the HDE, SLBP binding nucleates the formation of the processing complex.

== References ==
{{refbegin}}
* {{cite journal | vauthors = Williams AS, Marzluff WF | title = The sequence of the stem and flanking sequences at the 3′ end of histone mRNA are critical determinants for the binding of the stem-loop binding protein | journal = Nucleic Acids Research | volume = 23 | issue = 4 | pages = 654–662 | date = February 1995 | pmid = 7899087 | pmc = 306734 | doi = 10.1093/nar/23.4.654 }}
* {{cite journal | vauthors = Zanier K, Luyten I, Crombie C, Muller B, Schümperli D, Linge JP, Nilges M, Sattler M | title = Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression | journal = RNA | volume = 8 | issue = 1 | pages = 29–46 | date = January 2002 | pmid = 11871659 | pmc = 1370228 | doi = 10.1017/s1355838202014061 }}
* {{cite journal | vauthors = Zhang M, Lam TT, Tonelli M, Marzluff WF, Thapar R | title = Interaction of the histone mRNA hairpin with stem-loop binding protein (SLBP) and regulation of the SLBP-RNA complex by phosphorylation and proline isomerization | journal = Biochemistry | volume = 51 | issue = 15 | pages = 3215–3231 | date = April 2012 | pmid = 22439849 | pmc = 3328597 | doi = 10.1021/bi2018255 }}
{{refend}}

== External links ==
* {{Rfam|id=RF00032|name=Histone 3′ UTR stem-loop}}
* [https://web.archive.org/web/20081014051439/http://mrna.otago.ac.nz/cgi-bin/tt_data_browse/RNAMotif?PatID=T0101 Transterm page for Histone 3′ stem loop]
* [https://web.archive.org/web/20070920023314/http://www2.ba.itb.cnr.it/UTRSite/index.php/UTRSite%20signal/Signal/action/view/frmUTRSiteID/U0001/pageID/1/ UTRSite page for Histone 3′UTR stem-loop structure (HSL3)]

[[Category:Cis-regulatory RNA elements]]
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